John Morley, the retiring editor of a leading journal of medical gerontology, wrote a farewell editorial entitled "The Top 10 Hot Topics In Aging" (J. Gerontol. A Biol. Sci. Med. Sci. 59, 24-33; 2004). Not surprisingly, perhaps, cognitive decline was the first topic on his list. It is probably the single most feared aspect of growing old. It may also be among the most complex and least understood features of a host of age-related changes that can be summarized as senescent phenotypes.
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