Accessing a transporter structure

Michael P. Kavanaugh

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Accessing a transporter structure

机译：访问运输车结构

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In the brain, neurons communicate with each other primarily through the use of neurotransmitters. These chemical signals are released by presynaptic neurons in response to electrical impulses, then detected and converted back into electrical signals by receiving (postsynaptic) neurons. For this process to allow recurrent and selective signalling, the neurotransmitter must be efficiently removed soon after release. On page 811 of this issue, Yernool and colleagues describe the structure of an ancestral counterpart of the membrane transporter that is responsible for clearing glutamate — the predominant excitatory neurotransmitter in the mammalian central nervous system. This structure is the first to be obtained for a neurotransmitter-transporter-related protein. It is also the first amino-acid-transporter structure to be solved.

机译：在大脑中，神经元主要通过使用神经递质相互沟通。这些化学信号由突触前神经元响应电脉冲释放，然后通过接收（突触后）神经元进行检测并转换回电信号。为了使该过程能够反复出现和选择性发出信号，必须在释放后立即有效去除神经递质。在本期杂志的第811页上，Yernool及其同事描述了膜转运蛋白的祖先对应物的结构，该膜转运蛋白负责清除谷氨酸-哺乳动物中枢神经系统中主要的兴奋性神经递质。该结构是神经递质-转运蛋白相关蛋白的第一个获得的结构。它也是第一个要解决的氨基酸转运蛋白结构。

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来源
《Nature》 |2004年第7010期|p.752-753|共2页
作者
Michael P. Kavanaugh;
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作者单位

Center for Structural and Functional Neuroscience, University fo Montana 59812-1552, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Data structures and accessing in data-base systems, III: Data representations and the data independent accessing model [J] . IBM Systems Journal . 1973,第1期

机译：数据库系统中的数据结构和访问，III：数据表示形式和与数据无关的访问模型
2. Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions. [J] . Chiu CS, Jensen K, Sokolova I, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2002,第23期

机译：在携带GABA转运蛋白亚型1-绿色荧光蛋白融合蛋白的敲入小鼠的突触前结构中，GABA转运蛋白的数量，密度和表面/细胞质分布。
3. Neuronal, glial, and epithelial localization of gamma-aminobutyric acid transporter 2, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in the cerebral cortex and neighboring structures. [J] . Conti F, Zuccarello LV, Barbaresi P, The Journal of Comparative Neurology . 1999,第3期

机译：γ-氨基丁酸转运蛋白2（一种高亲和力的γ-氨基丁酸质膜转运蛋白）在大脑皮层和邻近结构中的神经元，神经胶质和上皮定位。
4. RFID-Based Access Human Transporter [C] . Sriram Sridharan, Ben Zoghi ASEE Annual Conference . 2009

机译：基于RFID的访问人体运输车
5. I. Structure-based molecular modeling and synthesis of indole derivatives as non-phenolic analogues of mycophenolic acid. II. 3D-QSAR studies using CoMFA on homotropane and tropane derivatives as dopamine transporter and serotonin transporter ligands. [D] . El-Araby, Moustafa El-Sayed. 2001

机译：I.基于结构的分子模型和吲哚衍生物作为霉酚酸的非酚类似物的合成。二。 3D-QSAR研究使用CoMFA对高碘烷和托烷衍生物作为多巴胺转运蛋白和5-羟色胺转运蛋白配体的研究。
6. Number Density and Surface/Cytoplasmic Distribution of GABA Transporters at Presynaptic Structures of Knock-In Mice Carrying GABA Transporter Subtype 1–Green Fluorescent Protein Fusions [O] . Chi-Sung Chiu, Kimmo Jensen, Irina Sokolova, 2002

机译：在携带GABA转运蛋白亚型1 –绿色荧光蛋白融合体的敲入小鼠突触前结构中GABA转运蛋白的数量密度和表面/细胞质分布
7. Alternating access and a pore-loop structure in the Na+-citrate transporter CitS of Klebsiella pneumoniae [O] . Sobczak I., Lolkema J.S., Sobczak No Value 2004

机译：肺炎克雷伯菌的Na +-柠檬酸盐转运蛋白CitS中的交替通道和孔-环结构

Accessing a transporter structure

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