Wnt-mediated axon guidance via the Drosophila derailed receptor

Yoshikawa S.; McKinnon RD.; Kokel M.; Thomas JB.

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Wnt-mediated axon guidance via the Drosophila derailed receptor

机译：Wnt介导的果蝇脱轨受体的轴突指导。

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In nervous systems with bilateral symmetry, many neurons project axons across the midline to the opposite side. In each segment of the Drosophila embryonic nervous system, axons that display this projection pattern choose one of two distinct tracts: the anterior or posterior commissure. Commissure choice is controlled by Derailed, an atypical receptor tyrosine kinase expressed on axons projecting in the anterior commissure. Here we show that Derailed keeps these axons out of the posterior commissure by acting as a receptor for Wnt5, a member of the Wnt family of secreted signalling molecules. Our results reveal an unexpected role in axon guidance for a Wnt family member, and show that the Derailed receptor is an essential component of Wnt signalling in these guidance events. [References: 50]

机译：在具有双边对称性的神经系统中，许多神经元将轴突穿过中线投射到另一侧。在果蝇胚胎神经系统的每个部分中，显示这种投射方式的轴突会选择两个不同的区域之一：前连合或后连合。联结的选择由Derailed控制，Derailed是在前联结处突出的轴突上表达的非典型受体酪氨酸激酶。在这里，我们显示出Derailed通过充当Wnt5（Wnt家族分泌信号分子的成员）的受体使这些轴突脱离后连合。我们的结果揭示了Wnt家族成员在轴突导向中的意想不到的作用，并表明脱轨受体是这些导向事件中Wnt信号传导的重要组成部分。 [参考：50]

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来源
《Nature》 |2003年第6932期|p. 583-588|共6页
作者
Yoshikawa S.; McKinnon RD.; Kokel M.; Thomas JB.;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Tyrosine kinase family; Robo receptors; Cns midline; Commissural axons; Ventral ectoderm; Wingless gene; Expression; Protein; Ryk; Differentiation;

机译：酪氨酸激酶家族;机器人受体;Cns中线;合轴突;腹外胚层;无翅基因;表达;蛋白;Ryk;差异化;

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1. Hindsight regulates photoreceptor axon targeting through transcriptional control of jitterbug/Filamin and multiple genes involved in axon guidance in Drosophila [J] . Oliva Carlos, Molina-Fernandez Claudia, Maureira Miguel, Developmental neurobiology . 2015,第9期

机译：Hindsight通过对Jitterbug / Filamin的转录控制以及果蝇中轴突指导中涉及的多个基因的转录控制来调节光感受器轴突的靶向作用。
2. A gain-of-function screen for genes that influence axon guidance Identifies the NF-kappa B protein dorsal and reveals a requirement for the kinase pelle in Drosophila photoreceptor axon targeting [J] . Minidorff EN, OKeefel DD, Labbe A, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2007,第4期

机译：影响轴突指导的基因的功能增益筛选鉴定了NF-κB蛋白质背侧并揭示了果蝇感光受体轴突靶向中对激酶颗粒的需求
3. A Gain-of-Function Screen for Genes That Influence Axon Guidance Identifies the NF-?B Protein Dorsal and Reveals a Requirement for the Kinase Pelle in Drosophila Photoreceptor Axon Targeting [J] . Alain Labbé, David D. OKeefe, Donald J. van Meyel, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2007,第4期

机译：影响轴突指导的基因的功能增益屏幕识别NF-ΔB蛋白背侧，并揭示了果蝇感光受体轴突靶向激酶颗粒的需求。
4. Measurement of Receptor-Binding Activity of Non-Steroidal Ecdysone Agonists Using in vitro Expressed Receptor Proteins (EcR/USP Complex) of Chilo suppressalis and Drosophila melanogaster [C] . Chieka Minakuchi, Yoshiaki Nakagawa, Manabu Kamimura, Pan-Pacific Conference on Pesticide Science . 2005

机译：使用体外表达受体蛋白（ECR / USP复合物）的非甾体蜕皮酶激动剂的受体结合活性的测量嗜睡抑制和果蝇黑素蛋白酶
5. In Vivo Structure-function Analysis of Drosophila Robo1, an Axon Guidance Receptor Critical for Midline Repulsive Signaling in the Embryonic Central Nervous System [D] . Brown, Haley. 2018

机译：在果蝇Robo1的体内结构函数分析中，胚胎中枢神经系统中线排斥信令至关重要的轴突引导受体
6. A Gain-of-Function Screen for Genes That Influence Axon Guidance Identifies the NF-κB Protein Dorsal and Reveals a Requirement for the Kinase Pelle in Drosophila Photoreceptor Axon Targeting [O] . Elizabeth N. Mindorff, David D. OKeefe, Alain Labbé, 2007

机译：影响轴突指导的基因的功能增益屏幕识别了NF-κB蛋白的背侧并揭示了果蝇感光受体轴突靶向激酶颗粒的需求。
7. A Gain-of-Function Screen for Genes That Influence Axon Guidance Identifies the NF-κB Protein Dorsal and Reveals a Requirement for the Kinase Pelle in Drosophila Photoreceptor Axon Targeting [O] . Mindorff, Elizabeth N., O'Keefe, David D., Labbé, Alain, 2007

机译：影响轴突指导的基因的功能增益屏幕确定了NF-κB蛋白的背侧，并揭示了果蝇感光受体轴突靶向激酶颗粒的需求。

Wnt-mediated axon guidance via the Drosophila derailed receptor

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