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首页> 外文期刊>Nature >Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
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Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing

机译：全基因组测序揭示了问号钩端螺旋体的独特生理和致病特征

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Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur(1). Here we report the complete genomic sequence of a representative virulent serovar type strain (Lai)(2) of Leptospira interrogans serogroup Icterohaemorrhagiae consisting of a 4.33-megabase large chromosome and a 359-kilobase small chromosome, with a total of 4,768 predicted genes. In terms of the genetic determinants of physiological characteristics, the facultatively parasitic L. interrogans differs extensively from two other strictly parasitic pathogenic spirochaetes, Treponema pallidum(3) and Borrelia burgdorferi(4), although similarities exist in the genes that govern their unique morphological features. A comprehensive analysis of the L. interrogans genes for chemotaxis/motility and lipopolysaccharide synthesis provides a basis for in-depth studies of virulence and pathogenesis. The discovery of a series of genes possibly related to adhesion, invasion and the haematological changes that characterize leptospirosis has provided clues about how an environmental organism might evolve into an important human pathogen. [References: 29]
机译：钩端螺旋体病是一种引起全球广泛关注的疾病。感染会引起类似流感的发作，并经常出现严重的肾脏和肝脏损害，例如出血和黄疸。在更严重的情况下，可能发生大规模的肺出血，包括致命的突然性咯血（1）。在这里，我们报告了钩端螺旋体血清群Icterohaemorrhagiae的典型毒力血清型毒株（Lai）（2）的完整基因组序列，由4.33兆碱基的大染色体和359千碱基的小染色体组成，共有4,768个预测基因。就生理学特征的遗传决定因素而言，尽管寄生于疟原虫的拟南芥与其他两个严格寄生于病原的螺旋体螺旋藻（Treponema pallidum（3）和伯氏疏螺旋体（Borrelia burgdorferi）（4））存在很大差异，但是控制它们独特形态特征的基因存在相似之处。 。对L. interrogans基因的趋化性/运动性和脂多糖合成的综合分析为深入研究毒力和发病机理提供了基础。一系列可能与钩端螺旋体病特征有关的粘附，侵袭和血液学变化相关基因的发现，为环境生物如何演变成重要的人类病原体提供了线索。 [参考：29]

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