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The genome sequence of the filamentous fungus Neurospora crassa

机译：丝状真菌Neurospora crassa的基因组序列

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Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 40-megabase genome encodes about 10,000 protein-coding genes-more than twice as many as in the fission yeast Schizosaccharomyces pombe and only about 25% fewer than in the fruitfly Drosophila melanogaster. Analysis of the gene set yields insights into unexpected aspects of Neurospora biology including the identification of genes potentially associated with red light photobiology, genes implicated in secondary metabolism, and important differences in Ca2+ signalling as compared with plants and animals. Neurospora possesses the widest array of genome defence mechanisms known for any eukaryotic organism, including a process unique to fungi called repeat-induced point mutation (RIP). Genome analysis suggests that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes. [References: 72]
机译：景天孢子虫是20世纪遗传学，生物化学和分子生物学史上的中心生物。在这里，我们报告了N. crassa基因组的高质量草图序列。大约40兆碱基的基因组编码约10,000个蛋白质编码基因，是裂变酵母粟酒裂殖酵母中的两倍多，仅比果蝇果蝇少25％。对基因集的分析可深入了解神经孢菌生物学的未曾预料到的方面，包括鉴定与红光光生物学相关的基因，与次级代谢有关的基因以及与植物和动物相比Ca2 +信号传导的重要差异。 Neurospora具有任何真核生物都知道的最广泛的基因组防御机制，包括真菌特有的称为重复诱导点突变（RIP）的过程。基因组分析表明，RIP对基因组进化产生了深远影响，通过基因组复制极大地减慢了新基因的产生，并导致紧密相关基因比例异常低的基因组。 [参考：72]

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