Taking the measure

Vicki Lundblad

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Taking the measure

机译：采取措施

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Telomeres ― the tips of chromosomes ― need to be preserved, and this involves replenishing telomeric DNA when it has been eroded. But telomeres must not become too long, and one aspect of length control is now revealed. In every organism, maintaining the integrity of the genome is a crucial endeavour. One aspect of genome maintenance involves protecting telomeres, the natural ends of linear chromosomes. This task is achieved by a suite of specialized protein complexes, which are anchored to chromosome ends through their association with further proteins that bind directly to telomeric DNA. The resulting structure prevents events that would be catastrophic for the genome, such as the loss of terminal DNA sequences or end-to-end chromosome fusions.

机译：端粒-染色体的尖端-必须得到保护，这涉及到端粒DNA被侵蚀后要对其进行补充。但是端粒不能太长，现在揭示了长度控制的一个方面。在每种生物中，维持基因组的完整性都是至关重要的。基因组维护的一方面涉及保护端粒（线性染色体的天然末端）。这项任务是通过一套专门的蛋白质复合物完成的，该复合物通过与其他直接结合端粒DNA的蛋白质缔合而锚定在染色体末端。最终的结构可防止发生对基因组具有灾难性的事件，例如末端DNA序列的丢失或端对端染色体融合。

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来源
《Nature》 |2003年第6943期|p.926-927|共2页
作者
Vicki Lundblad;
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作者单位

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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7. Proposal for Council Regulation (EEC) on the safeguard measures provided for in the Cooperation Agreement and the Interim Agreement between the European Economic Community and the Arab Republic of Egypt; Proposal for Council Regulation (EEC) on the safeguard measures provided for in the Cooperation Agreement and the Interim Agreement between the European Economic Community and the Hashemite Kingdom of Jordan; Proposal for Council Regulation (EEC) on the safeguard measures provided for in the Cooperation Agreement and the Interim Agreement between the European Economic Community and the Syrian Arab Republic; Proposal for Council Regulation (EEC)on the safeguard measures provided for in the Cooperation Agreement and the Interim Agreement between the European Economic Community and the Lebanese Republic; Proposal for Council Regulation on the safeguard measures provided for in the Cooperation Agreement and the Interim Agreement between the European Economic Community and the Kingdom of Morocco; Proposal for Council Regulation (EEC) on the safeguard measures provided for in the Cooperation Agreement and the Interim Agreement between the European Economic Community and the People's Democratic Republic of Algeria; Proposal for Council Regulation (EEC) on the safeguard measures provided for in the Cooperation Agreement and the Interim Agreement between the European Economic Community and the Republic of Tunisia. COM (77) 246 final, 6 June 1977. [O] . 1977

机译：关于理事会条例（EEC）关于合作协议和欧洲经济共同体与阿拉伯埃及共和国之间临时协议中规定的保障措施的提案;关于理事会条例（EEC）关于合作协议和欧洲经济共同体与约旦哈希姆王国之间的临时协议所规定的保障措施的提案;关于理事会条例（EEC）关于合作协议和欧洲经济共同体与阿拉伯叙利亚共和国之间临时协议规定的保障措施的提案;关于理事会条例（EEC）关于合作协议和欧洲经济共同体与黎巴嫩共和国之间临时协议规定的保障措施的提案;关于“合作协定”和“欧洲经济共同体与摩洛哥王国之间的临时协定”规定的保障措施的理事会条例的提案;关于“合作协议”和欧洲经济共同体与阿尔及利亚人民民主共和国之间的临时协议所规定的保障措施的理事会条例（EEC）的提案;关于“合作协议”和欧洲经济共同体与突尼斯共和国之间的临时协议中规定的保障措施的理事会条例（EEC）的提案。 COm（77）246决赛，1977年6月6日。

Taking the measure

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