Smad-dependent and Smad-independent pathways in TGF-beta family signalling [Review]

Derynck R.; Zhang YE.

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling [Review]

机译：TGF-beta家族信号传导中的依赖于Smad和Smad的途径[综述]

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Transforming growth factor-beta (TGF-beta) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-beta signalling, the Smad proteins, are activated by receptors and translocate into the nucleus, where they regulate transcription. Although this pathway is inherently simple, combinatorial interactions in the heteromeric receptor and Smad complexes, receptor-interacting and Smad-interacting proteins, and cooperation with sequence-specific transcription factors allow substantial versatility and diversification of TGF-beta family responses. Other signalling pathways further regulate Smad activation and function. In addition, TGF-beta receptors activate Smad-independent pathways that not only regulate Smad signalling, but also allow Smad-independent TGF-beta responses. [References: 101]

机译：转化生长因子-β（TGF-β）蛋白调节细胞功能，并在发育和致癌作用中起关键作用。 TGF-β信号转导的细胞内效应子Smad蛋白被受体激活并转移到细胞核中，在细胞核中调节转录。尽管此途径本质上很简单，但异聚受体和Smad络合物，受体相互作用和Smad相互作用蛋白中的组合相互作用以及与序列特异性转录因子的协同作用使TGF-beta家族应答具有相当大的通用性和多样性。其他信号传导途径进一步调节Smad激活和功能。另外，TGF-β受体激活不依赖Smad的途径，该途径不仅调节Smad信号传导，而且还允许不依赖Smad的TGF-β反应。 [参考：101]

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《Nature》 |2003年第6958期|p. 577-584|共8页
作者
Derynck R.; Zhang YE.;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Growth-factor-beta; Activated protein-kinase; Epithelial-cell plasticity; Anaphase-promoting complex; Cdk inhibitor p15(ink4b); Ubiquitin ligase complex; Transcriptional activation; Mesenchymal transdifferentiation; Adipocyte differentiation; Receptor internalization;

机译：生长因子-β;活化的蛋白激酶;上皮细胞可塑性;后期促进复合物;Cdk抑制剂p15（ink4b）;泛素连接酶复合物;转录激活;间质转分化;脂肪细胞分化;受体内在化;

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1. Fucoxanthin Inhibits Myofibroblast Differentiation and Extracellular Matrix Production in Nasal Polyp-Derived Fibroblasts via Modulation of Smad-Dependent and Smad-Independent Signaling Pathways [J] . Hyun Jung, Dae-Sung Lee, Seong Kook Park, Marine Drugs . 2018,第9期

机译：岩藻黄质通过调节Smad依赖性和Smad依赖性信号通路抑制鼻息肉成纤维细胞中的成纤维细胞分化和细胞外基质产生。
2. Smad-independent TGF-beta 2 signaling pathways in human trabecular meshwork cells [J] . Pervan Cynthia L. Experimental Eye Research . 2017,第期

机译：尚独立于无论的TGF-Beta 2在人小梁网状细胞中的信号通路
3. TGF-beta induces novel Lef-1 splice variants through a Smad-independent signaling pathway. [J] . Cordray P, Satterwhite DJ Developmental dynamics: an official publication of the American Association of Anatomists . 2005,第4期

机译：TGF-β通过独立于Smad的信号传导途径诱导新型Lef-1剪接变体。
4. Effect on TGF-beta Signaling Pathway of the Total Flavonoids from Valeriana jatamansi Jones in Hepatocarcinoma 22-bearing Mice [C] . Zhang Tiane, Chen Chaoyong, Chen Chong, Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on . 2012

机译：缬草总黄酮对22岁肝癌小鼠总黄酮类成分TGF-β信号通路的影响
5. Regulation of MAPK/JNK signaling pathway and TGF-beta signaling pathway by Axin. [D] . Rui, Hongliang. 2005

机译：Axin对MAPK / JNK信号通路和TGF-β信号通路的调节。
6. Fucoxanthin Inhibits Myofibroblast Differentiation and Extracellular Matrix Production in Nasal Polyp-Derived Fibroblasts via Modulation of Smad-Dependent and Smad-Independent Signaling Pathways [O] . Hyun Jung, Dae-Sung Lee, Seong Kook Park, 2018

机译：岩藻黄质通过调节Smad依赖性和Smad依赖性信号通路抑制鼻息肉成纤维细胞中的成纤维细胞分化和细胞外基质产生。
7. Fucoxanthin Inhibits Myofibroblast Differentiation and Extracellular Matrix Production in Nasal Polyp-Derived Fibroblasts via Modulation of Smad-Dependent and Smad-Independent Signaling Pathways [O] . Hyun Jung, Dae-Sung Lee, Seong Park, 2018

机译：通过调节依赖于依赖性和依赖无关的信号通路，岩藻素抑制鼻息肉衍生的成纤维细胞中的肌纤维增生和细胞外基质产生
8. Functional Role of the Casein Kinase I (CKI) Family in the Transforming Growth Factor-Beta (TGF-Beta) Signaling Pathway [R] . Waddell, D. , Liberati, N. T. , Wang, X. 2003

机译：酪蛋白激酶I（CKI）家族在转化生长因子-β（TGF-β）信号通路中的功能作用

Smad-dependent and Smad-independent pathways in TGF-beta family signalling [Review]

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