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Where's Waldo in yeast?

机译：酵母中的Waldo在哪里？

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摘要

Biologists have just completed a round of 'Where's Waldo?' with proteins of the yeast Saccharomyces cerevisiae. 'Where's Waldo?' is a popular children's game that entails finding every figure of Waldo in an intricately drawn picture. In some areas of the picture, Waldo blends in well with the background and is difficult to find; in others he stands out. Two papers in this issue (pages 686 and 737) describe large-scale studies of the yeast proteome, which had the goals of quantifying the levels of every protein expressed in yeast cells and determining the subcellular compartment in which the protein resides. Saccharomyces cerevisiae was the first eukaryote ― the type of organism characterized by a nucleus and membrane-bound organelles, which also includes humans―to have its genome sequenced3. Work with this organism has since led the way in functional genomics. Experiments pioneered in yeast have set the standard for the global analysis of cellular processes and paved the way for similar approaches in other organisms. They have also generated genome-wide collections of reagents that have been tremendously valuable.
机译：生物学家刚刚完成了一轮“瓦尔多在哪里？”与酵母的蛋白质。 “沃尔多在哪里？”是一款流行的儿童游戏，需要在一张复杂绘制的图片中找到Waldo的每个人物。在图片的某些区域，Waldo与背景融为一体，很难找到。在其他方面，他表现突出。该期的两篇论文（第686页和第737页）描述了酵母蛋白质组的大规模研究，其目的是量化酵母细胞中表达的每种蛋白质的水平并确定该蛋白质所驻留的亚细胞区室。酿酒酵母是第一种真核生物-一种具有核和膜结合细胞器（还包括人类）的生物体，其基因组已测序[3]。此后，与这种生物体的合作一直引领着功能基因组学的发展。酵母方面的先驱实验为细胞过程的整体分析设定了标准，并为其他生物中的类似方法铺平了道路。他们还产生了全基因组试剂的集合，这些都是非常有价值的。

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  • 来源
    《Nature》 |2003年第6959期|p.671-672|共2页
  • 作者

    James A. Wohlschlegel; John R. Yates;

  • 作者单位

    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
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