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Sperm from neonatal mammalian testes grafted in mice

机译：小鼠移植的新生哺乳动物睾丸的精子

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摘要

Spermatogenesis is a productive and highly organized process that generates virtually unlimited numbers of sperm during adulthood. Continuous proliferation and differentiation of germ cells occur in a delicate balance with other testicular compartments, especially the supporting Sertoli cells. Many complex aspects of testis function in humans and large animals have remained elusive because of a lack of suitable in vitro or in vivo models. Germ cell transplantation has produced complete donor-derived spermatogenesis in rodents but not in other mammalian species. Production of sperm in grafted tissue from immature mamalian testes and across species has not yet been accomplished. Hare we report the establishment of complete spermatogenesis by grafting testis tissue from newborn mice, pigs or goats into mouse hosts. This approach maintains structural integrity and provides the accessibility that is essential for studying and manipulating the function of testes and for preserving the male germ line. Our results indicate that this approach is applicable to diverse mammalian species.
机译：精子发生是一个有生产力且高度组织化的过程，在成年期几乎可以产生无限数量的精子。生殖细胞的持续增殖和分化与其他睾丸区室，尤其是支持性支持细胞之间形成微妙的平衡。由于缺乏合适的体外或体内模型，人类和大动物睾丸功能的许多复杂方面仍然难以捉摸。生殖细胞移植已在啮齿动物中产生了完整的供体来源的精子发生，但在其他哺乳动物中却没有。从尚未成熟的哺乳动物睾丸和跨物种的移植组织中生产精子尚未完成。野兔，我们报告了通过将新生小鼠，猪或山羊的睾丸组织移植到小鼠宿主中而建立了完整的精子形成过程。这种方法保持了结构的完整性，并提供了可访问性，这对于研究和操纵睾丸的功能以及保留雄性种系至关重要。我们的结果表明，这种方法适用于多种哺乳动物。

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