Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase

Jiaxu Li; Toshinori Kinoshita; Sona Pandey; Carl K.-Y. Ng; Steven P. Gygi; Ken-ichiro Shimazaki; Sarah M. Assmann

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Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase

机译：脱落酸激活蛋白激酶对RNA结合蛋白的调节

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Protein kinases are involved in stress signalling in both plant and animal systems. The hormone abscisic acid mediates the responses of plants to stresses such as drought, salinity and cold. Abscisic-acid-activated protein kinase (AAPK)― found in guard cells, which control stomatal pores― has been shown to regulate plasma membrane ion channels. Here we show that AAPK―interacting protein 1 (AKIP1), with sequence homology to heterogeneous nuclear RNA-binding protein A/B, is a substrate of AAPK. APK-dependent phosphorylation is required for the interaction of AKIP1 with messenger RNA that encodes dehy-drin, a protein implicated in cell protection under stress conditions. AAPK and AKIP1 are present in the guard-cell nucleus, and in vivo treatment of such cells with abscisic acid enhances the partitioning of AKIP1 into subnuclear foci which are reminiscent of nuclear speckles. These results show that phosphorylation-regulated RNA target discrimination by heterogeneous nuclcar RNA-binding proteins may be a general phenomenon in eukar-yotes, and implicate a plant hormone in the regulation of protein dynamics during rapid subnuclear reorganization.

机译：蛋白激酶参与植物和动物系统的应激信号传递。脱落酸激素介导植物对干旱，盐碱和寒冷等胁迫的反应。保卫细胞中存在的脱落酸激活蛋白激酶（AAPK）控制着气孔，已被证明可以调节质膜离子通道。在这里，我们显示与异质核RNA结合蛋白A / B具有序列同源性的AAPK相互作用蛋白1（AKIP1）是AAPK的底物。 AKIP1与编码脱氢蛋白的信使RNA相互作用需要APK依赖的磷酸化，脱氢蛋白是一种在应激条件下参与细胞保护的蛋白。 AAPK和AKIP1存在于保卫细胞核中，在体内用脱落酸处理此类细胞可增强AKIP1在亚核灶中的分配，这使人联想到核斑点。这些结果表明异核核糖RNA结合蛋白的磷酸化调节的RNA靶标识别可能是真核生物中的普遍现象，并且在快速亚核重组过程中暗示了植物激素对蛋白质动力学的调节。

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《Nature》 |2002年第6899期|p.793-797|共5页
作者
Jiaxu Li; Toshinori Kinoshita; Sona Pandey; Carl K.-Y. Ng; Steven P. Gygi; Ken-ichiro Shimazaki; Sarah M. Assmann;
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作者单位

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway [J] . Francisco Prieto-Ruiz, Jero Vicente-Soler, Alejandro Franco, MBio . 2020,第1期

机译：RNA结合蛋白RNC1通过应力激活的丝裂剂活化蛋白激酶途径的负反馈调节调节裂变酵母的裂变酵母中的肝脏长度和急性应激反应
2. G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A [J] . Anne Kristin Aksaas, Anja CV Larsen, Marie Rogne, Journal of molecular signaling . 2011,第1期

机译：G-补丁域和含有KOW基序的蛋白GPKOW;由蛋白激酶A调节的核RNA结合蛋白
3. Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen. [J] . A Gatignol, C Buckler, K T Jeang Molecular and Cellular Biology . 1993,第4期

机译：人免疫缺陷病毒1型TAR RNA结合蛋白TRBP中RNA结合基序与人P1 / dsI激酶和果蝇Staufen的相关性。
4. Function driven protein evolution. A possible proto-protein for the RNA-binding proteins [C] . Jacquelyn S. Fetrow, Adam Godzik Pacific Symposium on Biocomputing '98 4-9 January 1998 Maui, Hawaii, USA . 1998

机译：功能驱动的蛋白质进化。 RNA结合蛋白的可能原蛋白
5. Characterization of two RNA-binding proteins containing RNA-Recognition Motif (RRM)-type RNA-binding domains from mouse brain. [D] . Inman, Michael Verne. 1999

机译：表征两个RNA结合蛋白的小鼠大脑中的RNA识别基序（RRM）型RNA结合域。
6. RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway [O] . Francisco Prieto-Ruiz, Jero Vicente-Soler, Alejandro Franco, 2020

机译：RNA结合蛋白Rnc1调节裂变酵母中分裂和急性应激反应的细胞长度通过应力激活的丝裂原激活的蛋白激酶途径的负反馈调制。
7. RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway [O] . Francisco Prieto-Ruiz, Jero Vicente-Soler, Alejandro Franco, 2020

机译：RNA结合蛋白RNC1通过应力激活的丝裂剂活化蛋白激酶途径的负反馈调节调节裂变酵母的裂变酵母中的肝脏长度和急性应激反应
8. Characterization of the Sites Phosphorylated on Tyrosine Hydroxylase by Ca(2+) and Phospholipid-Dependent Protein Kinase, Calmodulin-Dependent Multiprotein Kinase and Cyclic AMP-Dependent Protein Kinase [R] . Vulliet, P. R., Woodgett, J. R., Ferrari, S., 1985

机译：通过Ca（2+）和磷脂依赖性蛋白激酶，钙调蛋白依赖性多蛋白激酶和环amp依赖性蛋白激酶在酪氨酸羟化酶上磷酸化位点的表征

Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase

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