Obesity in the new millennium

J. M. Friedman

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Obesity in the new millennium

机译：新千年肥胖

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Obesity has increased at an alarming rate in recent years and is now a worldwide public health problem. In addition to suffering poor health and an increased risk of illnesses such as hypertension and heart disease, obese people are often stigmatized socially. But major advances have now been made in identifying the components of the homeostatic system that regulates body weight, including several of the genes responsible for animal and human obesity. A key element of the physiological system is the hormone leptin, which acts on nerve cells in the brain (and elsewhere) to regulate food intake and body weight. The identification of additional molecules that comprise this homeostatic system will provide further insights into the molecular basis of obesity, and possibilities for new treatments.

机译：肥胖症近年来以惊人的速度增长，现在已成为全球性的公共卫生问题。除了健康状况不佳以及患高血压和心脏病等疾病的风险增加外，肥胖者在社会上常常受到污名化。但是，现在已经在鉴定调节体重的稳态系统的组成方面取得了重大进展，其中包括负责动物和人类肥胖的几种基因。生理系统的关键元素是瘦素激素，它作用于大脑（和其他部位）的神经细胞，以调节食物的摄入量和体重。鉴定组成该稳态系统的其他分子将为肥胖的分子基础提供进一步的见识，并为新疗法提供可能性。

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《Nature》 |2000年第6778期|p.632-634|共3页
作者
J. M. Friedman;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：青少年肥胖症的家庭收入梯度，超重和肥胖在极其贫困和极其富裕的社区坚持，但不在中产阶级社区：来自英国千年队列研究的证据

Obesity in the new millennium

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