Conditioning and opiate withdrawal

G. Schulteis; S. H. Ahmed; A. C. Morse; G. F. Koob; B. J. Everitt

首页> 外文期刊>Nature >Conditioning and opiate withdrawal

【24h】

Conditioning and opiate withdrawal

机译：调理和鸦片戒断

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The habitual behaviour of many opiate addicts means that the aversive symptoms of drug withdrawal are frequently experienced in specific environments. Stimuli in these environments acquire some of the negative affective properties of opiate withdrawal through pavlovian conditioning, and subsequent exposure to these stimuli alone can then elicit a conditioned withdrawal response that is often associated with drug craving, drug seeking, and relapse back to compulsive drug use after a long abstinence. We show here that selective excitotoxic lesions of the basolateral amygdala, part of the limbic forebrain, prevent the development of conditioned withdrawal in morphine-dependent rats.

机译：许多鸦片上瘾者的习惯行为意味着在特定环境中经常会出现戒毒的厌恶症状。在这些环境中，刺激通过帕夫洛夫病条件获得鸦片戒断的某些负面情感特性，随后仅暴露于这些刺激下即可引发条件戒断反应，这种反应通常与药物渴望，寻求药物以及复发性强迫性吸毒相关经过长时间的禁欲。我们在这里显示了基底外侧杏仁核（部分前脑的一部分）的选择性兴奋性毒性损害，在吗啡依赖性大鼠中阻止条件性戒断的发展。

著录项

来源
《Nature》 |2000年第6790期|p.1013-1014|共2页
作者
G. Schulteis; S. H. Ahmed; A. C. Morse; G. F. Koob; B. J. Everitt;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Interference with withdrawal signs of naloxone-induced opiate withdrawal under anesthesia is anesthetic-specific in opiate-dependent rats. [J] . Streel E, Dan B, Bredas P, Life sciences . 2001,第5期

机译：在麻醉鸦片依赖的大鼠中，麻醉对纳洛酮诱导的鸦片撤药的撤药迹象的干预是麻醉剂特异性的。
2. Extinction of conditioned opiate withdrawal in rats is blocked by intracerebroventricular infusion of an NMDA receptor antagonist [J] . ColemanB.R., CarlezonJr.W.A., MyersK.M. Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2013,第Null期

机译：脑室内注入NMDA受体拮抗剂可阻止大鼠条件性鸦片撤药的灭绝
3. Reactivity and plasticity in the amygdala nuclei during opiate withdrawal conditioning: differential expression of c-fos and arc immediate early genes. [J] . Lucas M, Frenois F, Vouillac C, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2008,第3期

机译：阿片戒断条件下杏仁核中的反应性和可塑性：c-fos和arc立即早期基因的差异表达。
4. Application of MM waves in the therapy of withdrawal syndrome for opiate-dependent patients [C] . Glazyrina, N.I., Abolonin, . 2003

机译：MM波在阿片依赖患者戒断综合征治疗中的应用
5. Discrimination of an antagonist-precipitated withdrawal from an acute state of opiate dependence in rats. [D] . Jones, Nicholas Tyson. 2005

机译：在大鼠中从鸦片依赖的急性状态中识别出拮抗剂导致的戒断。
6. Extinction of conditioned opiate withdrawal in rats in a two-chambered place conditioning apparatus [O] . Karyn M. Myers, Anita J. Bechtholt-Gompf, Brian R. Coleman, -1

机译：在两室的地方调节装置在大鼠中的条件戒断灭绝
7. Interference with withdrawal signs of naloxone-induced opiate withdrawal under anesthesia is anesthetic-specific in opiate-dependent rats. [O] . Streel, Emmanuel, Dan, Bernard, Bredas, Philippe, 2001

机译：在麻醉鸦片依赖的大鼠中，麻醉对纳洛酮诱发的鸦片鸦片撤药的干扰迹象是麻醉剂特异性的。
8. Poppy Seed Consumption or Opiate Use: The Determination of Thebaine and Opiates of Abuse in Postmortem Fluids and Tissues Final rept [R] . Johnson, R. D. 2005

机译：罂粟籽消费或鸦片使用：死后液体和组织中蒂巴因和阿片类药物的测定最终报告

Conditioning and opiate withdrawal

摘要

著录项

相似文献

相关主题

期刊订阅