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Microtubule motors in mitosis

机译:微管马达在有丝分裂

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The mitotic spindle uses microtubule-based motor proteins to assemble itself and to segregate sister chromatids. It is becoming clear that motors invoke several distinct mechanisms to generate the forces that drive mitosis. Moreover, in carrying out its function, the spindle appears to pass through a series of transient steady-state structures, each established by a delicate balance of forces generated by multiple complementary and antagonistic motors. Transitions from one steady state to the next can occur when a change in the activity of a subset of mitotic motors tips the balance.
机译:有丝分裂纺锤体使用基于微管的运动蛋白组装自身并分离姐妹染色单体。越来越清楚的是,电动机会调用几种不同的机制来产生驱动有丝分裂的力。此外,在执行其功能时,主轴似乎要经过一系列瞬态稳态结构,每个瞬态稳态结构都是由多个互补和对立电机产生的力的精细平衡所建立的。当有丝分裂运动的子集的活动的变化使平衡达到平衡时,可能会发生从一种稳态到另一种稳态的转变。

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