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Development of a preventive vaccine for Ebola virus infection in primates

机译：灵长类动物埃博拉病毒感染预防疫苗的研制

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Outbreaks of haemorrhagic fever caused by the Ebola virus are associated with high mortality rates that are a distinguishing feature of this human pathogen. The highest lethality is associated with the Zaire subtype, one of four strains identified to date. Its rapid progression allows little opportunity to develop natural immunity, and there is currently no effective anti-viral therapy. Therefore, vaccination offers a promising intervention to prevent infection and limit spread. Here we describe a highly effective vaccine strategy for Ebola virus infection in non-human primates. A combination of DNA immunization and boosting with adeno-viral vectors that encode viral proteins generated cellular and humoral immunity in cynomolgus macaques. Challenge with a lethal dose of the highly pathogenic, wild-type, 1976 Mayinga strain of Ebola Zaire virus resulted in uniform infection in controls, who progressed to a moribund state and death in less than one week. In contrast, all vaccinated animals were asymptomatic for more than six months, with no detectable virus after the initial challenge. These findings demonstrate that it is possible to develop a preventive vaccine against Ebola virus infection in primates.
机译：埃博拉病毒引起的出血热暴发与高死亡率有关，高死亡率是这种人类病原体的显着特征。最高的致死率与Zaire亚型有关，Zaire亚型是迄今为止确定的四种菌株之一。它的快速发展几乎没有机会发展自然免疫力，目前还没有有效的抗病毒治疗方法。因此，接种疫苗为预防感染和限制传播提供了有希望的干预措施。在这里，我们描述了一种针对非人类灵长类动物的埃博拉病毒感染的高效疫苗策略。 DNA免疫和编码病毒蛋白的腺病毒载体的组合在食蟹猕猴中产生了细胞和体液免疫。用致死剂量的高致病性野生型1976年Mayinga埃博拉扎伊尔病毒菌株进行攻击，导致对照中出现统一感染，对照组进展为垂死状态，并在不到一周的时间内死亡。相反，所有接种疫苗的动物均无症状超过六个月，在最初攻击后没有可检测到的病毒。这些发现表明，有可能开发出针对灵长类动物的埃博拉病毒感染的预防性疫苗。

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