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Sleep modulates haematopoiesis and protects against atherosclerosis

机译：睡眠可调节造血功能并预防动脉粥样硬化

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摘要

Sleep is integral to life(1). Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular disease(2), we know little about the cellular and molecular mechanisms by which sleep maintains cardiovascular health. Here we report that sleep regulates haematopoiesis and protects against atherosclerosis in mice. We show that mice subjected to sleep fragmentation produce more Ly-6C(high) monocytes, develop larger atherosclerotic lesions and produce less hypocretin-a stimulatory and wake-promoting neuropeptide-in the lateral hypothalamus. Hypocretin controls myelopoiesis by restricting the production of CSF1 by hypocretin-receptor-expressing pre-neutrophils in the bone marrow. Whereas hypocretin-null and haematopoietic hypocretin-receptor-null mice develop monocytosis and accelerated atherosclerosis, sleep-fragmented mice with either haematopoietic CSF1 deficiency or hypocretin supplementation have reduced numbers of circulating monocytes and smaller atherosclerotic lesions. Together, these results identify a neuro-immune axis that links sleep to haematopoiesis and atherosclerosis.
机译：睡眠是生命不可或缺的部分（1）。尽管睡眠不足或睡眠中断会增加多种病理状况（包括心血管疾病）的风险（2），但我们对睡眠维持心血管健康的细胞和分子机制知之甚少。在这里我们报告睡眠调节造血功能，并防止小鼠的动脉粥样硬化。我们表明，遭受睡眠破碎的小鼠产生更多的Ly-6C（high）单核细胞，发展成更大的动脉粥样硬化病变，并在下丘脑外侧产生较少的降血钙素-一种刺激和唤醒的神经肽。降钙素通过在骨髓中表达表达降钙素受体的前中性粒细胞来限制CSF1的产生，从而控制骨髓生成。降血糖素无效和造血降钙素受体无效的小鼠会发展为单核细胞增多症并加速动脉粥样硬化，而睡眠分裂的小鼠若缺乏造血CSF1或补充降钙素，则循环单核细胞数量减少，动脉粥样硬化病变较小。总之，这些结果确定了将睡眠与造血功能和动脉粥样硬化联系在一起的神经免疫轴。

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  • 来源
    《Nature》 |2019年第7744期|383-387|共5页
  • 作者

    McAlpine Cameron S.; Kiss Mate G.; Rattik Sara; He Shun; Vassalli Anne; Valet Colin; Anzai Atsushi; Chan Christopher T.; Mindur John E.; Kahles Florian; Poller Wolfram C.; Frodermann Vanessa; Fenn Ashley M.; Gregory Annemijn F.; Halle Lennard; Iwamoto Yoshiko; Hoyer Friedrich F.; Binder Christoph J.; Libby Peter; Tafti Mehdi; Scammell Thomas E.; Nahrendorf Matthias; Swirski Filip K.;

  • 作者单位

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA|Med Univ Vienna, Dept Lab Med, Vienna, Austria|Austrian Acad Sci, CeMM Res Ctr Mol Med, Vienna, Austria;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Univ Lausanne, Fac Biol & Med, Dept Physiol, Lausanne, Switzerland;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA;

    Med Univ Vienna, Dept Lab Med, Vienna, Austria|Austrian Acad Sci, CeMM Res Ctr Mol Med, Vienna, Austria;

    Brigham & Womens Hosp, Dept Med, Cardiovasc Div, 75 Francis St, Boston, MA 02115 USA;

    Univ Lausanne, Fac Biol & Med, Dept Physiol, Lausanne, Switzerland;

    Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA;

    Harvard Med Sch, Boston, MA 02115 USA|Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA;

    Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA 02115 USA|Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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