From discoveries in ageing research to therapeutics for healthy ageing

Campisi Judith; Kapahi Pankaj; Lithgow Gordon J.; Melov Simon; Newman John C.; Verdin Eric

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From discoveries in ageing research to therapeutics for healthy ageing

机译：从衰老研究的发现到健康衰老的疗法

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For several decades, understanding ageing and the processes that limit lifespan have challenged biologists. Thirty years ago, the biology of ageing gained unprecedented scientific credibility through the identification of gene variants that extend the lifespan of multicellular model organisms. Here we summarize the milestones that mark this scientific triumph, discuss different ageing pathways and processes, and suggest that ageing research is entering a new era that has unique medical, commercial and societal implications. We argue that this era marks an inflection point, not only in ageing research but also for all biological research that affects the human healthspan.

机译：几十年来，对衰老和限制寿命的过程的了解一直困扰着生物学家。 30年前，衰老生物学通过鉴定可延长多细胞模型生物寿命的基因变异获得了前所未有的科学信誉。在这里，我们总结了标志着这一科学成就的里程碑，讨论了不同的衰老途径和过程，并建议衰老研究正在进入一个具有独特医学，商业和社会意义的新时代。我们认为，这个时代标志着一个拐点，不仅在衰老研究中，而且在影响人类健康的所有生物学研究中也是如此。

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来源
《Nature》 |2019年第7764期|183-192|共10页
作者
Campisi Judith; Kapahi Pankaj; Lithgow Gordon J.; Melov Simon; Newman John C.; Verdin Eric;
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作者单位

Buck Inst Res Aging, Novato, CA 94945 USA;

Buck Inst Res Aging, Novato, CA 94945 USA;

Buck Inst Res Aging, Novato, CA 94945 USA;

Buck Inst Res Aging, Novato, CA 94945 USA;

Buck Inst Res Aging, Novato, CA 94945 USA;

Buck Inst Res Aging, Novato, CA 94945 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. From discoveries in ageing research to therapeutics for healthy ageing [J] . Campisi Judith, Kapahi Pankaj, Lithgow Gordon J., Nature . 2019,第7764期

机译：从衰老研究对健康老龄化治疗的发现
2. Ageing/Menopausal Status in Healthy Women and Ageing in Healthy Men Differently Affect Cardiometabolic Parameters [J] . Ilaria Campesi, Stefano Occhioni, Giancarlo Tonolo, International Journal of Medical Sciences . 2016,第2期

机译：健康女性的衰老/更年期状况和健康男性的衰老对心脏代谢参数的影响不同
3. Progression in healthy ageing: frailty, cognitive decline and gender in the European Innovation Partnership for Active and Healthy Ageing [J] . Carretero Lidon, Navarro-Pardo Esperanza, Cano Antonio The European journal of psychiatry . 2015,第4期

机译：健康老龄化的进展：积极主动和健康老龄化的欧洲创新伙伴关系中的脆弱，认知能力下降和性别
4. The ACTIVAGE Marketplace: Hybrid Logic- and Text-Based Discovery of Active and Healthy Ageing IoT Applications [C] . Thanos G. Stavropoulos, Dimitris Strantsalis, Spiros Nikolopoulos, International Symposium on Ambient Intelligence . 2020

机译：激活市场：混合逻辑和基于文本的主动和健康老化IOT应用程序的发现
5. Health and Ageing in a Hostile Environment: Understanding Older Asylum Applicants' Narratives of Life, Health and Ageing in the UK [D] . Tomkow, Louise. 2019

机译：敌对环境中的健康和老龄化：了解英国的较古老的庇护申请人的生命叙事，健康和老龄化
6. Ageing/Menopausal Status in Healthy Women and Ageing in Healthy Men Differently Affect Cardiometabolic Parameters [O] . Ilaria Campesi, Stefano Occhioni, Giancarlo Tonolo, 2016

机译：健康女性的衰老/更年期状况和健康男性的衰老对心脏代谢参数的影响不同
7. Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project [O] . Calderon, M A, Demoly, P, Casale, T, 2016

机译：贯穿整个生命周期的过敏免疫疗法，以促进活跃和健康的衰老：从研究到政策：AIRWAYS综合护理途径（ICPs）计划项目（活跃和健康的衰老欧洲创新伙伴关系的行动计划B3）和全球慢性呼吸道联盟疾病（GARD），世界卫生组织GARD研究示范项目

From discoveries in ageing research to therapeutics for healthy ageing

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