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The Integrative Human Microbiome Project

机译：整合人类微生物组计划

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摘要

The NIH Human Microbiome Project (HMP) has been carried out over ten years and two phases to provide resources, methods, and discoveries that link interactions between humans and their microbiomes to health-related outcomes. The recently completed second phase, the Integrative Human Microbiome Project, comprised studies of dynamic changes in the microbiome and host under three conditions: pregnancy and preterm birth; inflammatory bowel diseases; and stressors that affect individuals with prediabetes. The associated research begins to elucidate mechanisms of host-microbiome interactions under these conditions, provides unique data resources (at the HMP Data Coordination Center), and represents a paradigm for future multi-omic studies of the human microbiome.
机译：NIH人类微生物组计划（HMP）已经进行了十年，分两个阶段进行，旨在提供资源，方法和发现，将人类及其微生物群之间的相互作用与健康相关的结果联系起来。最近完成的第二阶段，“综合人类微生物组计划”，包括在以下三个条件下对微生物组和宿主动态变化的研究：怀孕和早产；炎症性肠病;和影响糖尿病前期个体的压力源。相关研究开始阐明在这些条件下宿主-微生物组相互作用的机制，提供了独特的数据资源（在HMP数据协调中心），并代表了未来人类微生物组的多组学研究的范例。

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  • 来源
    《Nature》 |2019年第7758期|641-648|共8页
  • 作者

    Proctor Lita M.; Creasy Heather H.; Fettweis Jennifer M.; Lloyd-Price Jason; Mahurkar Anup; Zhou Wenyu; Buck Gregory A.; Snyder Michael P.; Strauss Jerome F. III; Weinstock George M.; White Owen; Huttenhower Curtis;

  • 作者单位

    NHGRI, NIH, Bethesda, MD 20892 USA|Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA;

    Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA|Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA;

    Virginia Commonwealth Univ, Dept Microbiol & Immunol, Sch Med, Richmond, VA 23298 USA|Virginia Commonwealth Univ, Dept Obstet & Gynecol, Sch Med, Med Coll Virginia Campus, Richmond, VA 23284 USA|Virginia Commonwealth Univ, Ctr Microbiome Engn & Data Anal, Med Coll Virginia Campus, Richmond, VA 23284 USA;

    Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA|Broad Inst MIT & Harvard, Cambridge, MA 02142 USA;

    Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA;

    Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA;

    Virginia Commonwealth Univ, Dept Microbiol & Immunol, Sch Med, Richmond, VA 23298 USA|Virginia Commonwealth Univ, Ctr Microbiome Engn & Data Anal, Med Coll Virginia Campus, Richmond, VA 23284 USA|Virginia Commonwealth Univ, Dept Comp Sci, Coll Engn, Med Coll Virginia Campus, Richmond, VA 23284 USA;

    Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA|Stanford Ctr Genom & Personalized Med, Stanford, CA 94305 USA|Stanford Diabet Res Ctr, Stanford, CA 94305 USA;

    Virginia Commonwealth Univ, Dept Obstet & Gynecol, Sch Med, Med Coll Virginia Campus, Richmond, VA 23284 USA|Virginia Commonwealth Univ, Ctr Microbiome Engn & Data Anal, Med Coll Virginia Campus, Richmond, VA 23284 USA;

    Jackson Lab Genom Med, Farmington, CT 06032 USA;

    Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA;

    Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA|Broad Inst MIT & Harvard, Cambridge, MA 02142 USA|Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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