Transcription factors and 3D genome conformation in cell-fate decisions

Stadhouders Ralph; Filion Guillaume J.; Graf Thomas

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Transcription factors and 3D genome conformation in cell-fate decisions

机译：细胞命运决定中的转录因子和3D基因组构象

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How cells adopt different identities has long fascinated biologists. Signal transduction in response to environmental cues results in the activation of transcription factors that determine the gene-expression program characteristic of each cell type. Technological advances in the study of 3D chromatin folding are bringing the role of genome conformation in transcriptional regulation to the fore. Characterizing this role of genome architecture has profound implications, not only for differentiation and development but also for diseases including developmental malformations and cancer. Here we review recent studies indicating that the interplay between transcription and genome conformation is a driving force for cell-fate decisions.

机译：细胞如何采用不同的身份早已使生物学家着迷。响应环境提示的信号转导导致转录因子的活化，该转录因子决定每种细胞类型的基因表达程序特征。 3D染色质折叠研究的技术进步使基因组构象在转录调控中的作用突显出来。表征基因组结构的这一作用具有深远的意义，不仅对于分化和发育，而且对于包括发育畸形和癌症在内的疾病也具有深远的意义。在这里，我们审查最近的研究表明，转录和基因组构象之间的相互作用是决定细胞命运的驱动力。

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来源
《Nature》 |2019年第7756期|345-354|共10页
作者
Stadhouders Ralph; Filion Guillaume J.; Graf Thomas;
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作者单位

Erasmus MC, Dept Pulm Med, Rotterdam, Netherlands|Erasmus MC, Dept Cell Biol, Rotterdam, Netherlands;

Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain|UPF, Barcelona, Spain;

Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain|UPF, Barcelona, Spain;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. Transcription factors and 3D genome conformation in cell-fate decisions [J] . Stadhouders Ralph, Filion Guillaume J., Graf Thomas Nature . 2019,第7756期

机译：细胞命运决策中的转录因子和3D基因组构象
2. Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. [J] . Thieu VT, Yu Q, Chang HC, Immunity . 2008,第5期

机译：转录因子T-bet促进T辅助1细胞命运的确定需要信号转导和转录激活因子4。
3. The 3D Genome in Transcriptional Regulation and PluripotencyThe 3D Genome in Transcriptional Regulation and Pluripotency [J] . David U. Gorkin, Danny Leung, Bing Ren Cell stem cell . 2014,第6期

机译：3D基因组的转录调控和多能性3D基因组的转录调控和多能性
4. Genome-wide identification of TSS, promoters and transcriptional factor binding sites in E. coli K-12 bacterial genome: Development of a bioinformatics tool for the graphical display of the high throughput sequencing data [C] . Enrique Morett, Leticia Vega-Alvarado, Ryosuke L.A.Watanabe, The 7th Asia-Pacific Bioinformatics Conference（第七届亚太生物信息学大会） . 2009

机译：大肠杆菌K-12细菌基因组中TSS，启动子和转录因子结合位点的全基因组鉴定：开发用于以图形方式显示高通量测序数据的生物信息学工具
5. Statistical Topology of Genome Analysis: From Chromosome Conformation Capture Data to 3D Structure [D] . Pouokam, Maxime Guiffo. 2020

机译：基因组分析的统计拓扑：从染色体构象捕获数据到3D结构
6. A tale of two cell-fates: role of the Hippo signaling pathway and transcription factors in early lineage formation in mouse preimplantation embryos [O] . Challis Karasek, Mohamed Ashry, Chad S Driscoll, -1

机译：两种细胞命运的故事：河马信号通路和转录因子在小鼠灌注胚胎中的早期谱系中的作用
7. Signal Transducer and Activator of Transcription 4 Is Required for the Transcription Factor T-bet to Promote T Helper 1 Cell-Fate Determination [O] . Thieu Vivian T., Yu Qing, Chang Hua-Chen, 2008

机译：转录因子T-bet促进T辅助1细胞命运的确定需要信号转导和转录激活因子4

Transcription factors and 3D genome conformation in cell-fate decisions

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