Plant cell-surface GIPC sphingolipids sense salt to trigger Ca~(2+) influx

Jiang Zhonghao; Zhou Xiaoping; Tao Ming; Yuan Fang; Liu Lulu; Wu Feihua; Wu Xiaomei; Xiang Yun; Niu Yue; Liu Feng; Li Chijun; Ye Rui; Byeon Benjamin; Xue Yan; Zhao Hongyan; Wang Hsin-Neng; Crawford Bridget M.; Johnson Douglas M.; Hu Chanxing; Pei Christopher; Zhou Wenming; Swift Gary B.; Zhang Han; Tuan Vo-Dinh; Hu Zhangli; Siedow James N.; Pei Zhen-Ming

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Plant cell-surface GIPC sphingolipids sense salt to trigger Ca~(2+) influx

机译：植物细胞表面的GIPC鞘脂感觉盐触发Ca〜（2+）流入

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Salinity is detrimental to plant growth, crop production and food security worldwide. Excess salt triggers increases in cytosolic Ca2+ concentration, which activate Ca2+-binding proteins and upregulate the Na+/H+ antiporter in order to remove Na+. Salt-induced increases in Ca2+ have long been thought to be involved in the detection of salt stress, but the molecular components of the sensing machinery remain unknown. Here, using Ca2+-imaging-based forward genetic screens, we isolated the Arabidopsis thaliana mutant monocation-induced [Ca2+](i) increases 1 (moca1), and identified MOCA1 as a glucuronosyltransferase for glycosyl inositol phosphorylceramide (GIPC) sphingolipids in the plasma membrane. MOCA1 is required for salt-induced depolarization of the cell-surface potential, Ca2+ spikes and waves, Na+/H+ antiporter activation, and regulation of growth. Na+ binds to GIPCs to gate Ca2+ influx channels. This salt-sensing mechanism might imply that plasma-membrane lipids are involved in adaption to various environmental salt levels, and could be used to improve salt resistance in crops.

机译：盐度不利于全世界的植物生长，作物生产和粮食安全。过量的盐触发因素会增加细胞内Ca2 +的浓度，从而激活Ca2 +结合蛋白并上调Na + / H +反转运蛋白以去除Na +。长期以来，盐引起的Ca2 +的增加一直被认为与盐胁迫的检测有关，但传感机制的分子组成仍然未知。在这里，使用基于Ca2 +成像的正向遗传筛选，我们分离了拟南芥突变体单阳离子诱导的[Ca2 +]（i）增加1（moca1），并将MOCA1鉴定为血浆中糖基肌醇磷酸神经酰胺（GIPC）鞘脂的葡萄糖醛糖基转移酶。膜。盐诱导的细胞表面电位去极化，Ca2 +尖峰和波，Na + / H +反向转运激活和生长调节需要MOCA1。 Na +与GIPC结合以控制Ca2 +流入通道。这种盐感机制可能暗示血浆膜脂质参与了对各种环境盐水平的适应，并且可用于提高农作物的盐抗性。

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《Nature》 |2019年第7769期|341-346|共6页
作者
Jiang Zhonghao; Zhou Xiaoping; Tao Ming; Yuan Fang; Liu Lulu; Wu Feihua; Wu Xiaomei; Xiang Yun; Niu Yue; Liu Feng; Li Chijun; Ye Rui; Byeon Benjamin; Xue Yan; Zhao Hongyan; Wang Hsin-Neng; Crawford Bridget M.; Johnson Douglas M.; Hu Chanxing; Pei Christopher; Zhou Wenming; Swift Gary B.; Zhang Han; Tuan Vo-Dinh; Hu Zhangli; Siedow James N.; Pei Zhen-Ming;
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作者单位

Shenzhen Univ, Longhua Innovat Inst Biotechnol, Coll Life Sci & Oceanog, Shenzhen, Peoples R China|Duke Univ, Dept Biol, Durham, NC 27708 USA|Hangzhou Normal Univ, Coll Life & Environm Sci, Hangzhou, Zhejiang, Peoples R China|Duke Univ, Fitzpatrick Inst Photon, Durham, NC USA;

Hangzhou Normal Univ, Coll Life & Environm Sci, Hangzhou, Zhejiang, Peoples R China;

Shenzhen Univ, Longhua Innovat Inst Biotechnol, Coll Life Sci & Oceanog, Shenzhen, Peoples R China;

Duke Univ, Dept Biol, Durham, NC 27708 USA|Hangzhou Normal Univ, Coll Life & Environm Sci, Hangzhou, Zhejiang, Peoples R China;

Duke Univ, Dept Biol, Durham, NC 27708 USA|Hangzhou Normal Univ, Coll Life & Environm Sci, Hangzhou, Zhejiang, Peoples R China;

Shenzhen Univ, Longhua Innovat Inst Biotechnol, Coll Life Sci & Oceanog, Shenzhen, Peoples R China|Duke Univ, Dept Biol, Durham, NC 27708 USA|Hangzhou Normal Univ, Coll Life & Environm Sci, Hangzhou, Zhejiang, Peoples R China;

Hangzhou Normal Univ, Coll Life & Environm Sci, Hangzhou, Zhejiang, Peoples R China;

Duke Univ, Dept Biol, Durham, NC 27708 USA;

Duke Univ, Dept Biol, Durham, NC 27708 USA;

Duke Univ, Dept Biol, Durham, NC 27708 USA;

Duke Univ, Dept Biol, Durham, NC 27708 USA;

Duke Univ, Dept Biol, Durham, NC 27708 USA;

Duke Univ, Dept Biol, Durham, NC 27708 USA;

Duke Univ, Dept Biol, Durham, NC 27708 USA;

Hangzhou Normal Univ, Coll Life & Environm Sci, Hangzhou, Zhejiang, Peoples R China;

Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA;

Duke Univ, Fitzpatrick Inst Photon, Durham, NC USA|Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA;

Duke Univ, Dept Phys, Durham, NC 27706 USA;

Duke Univ, Dept Biol, Durham, NC 27708 USA;

Duke Univ, Dept Biol, Durham, NC 27708 USA;

Shenzhen Univ, Longhua Innovat Inst Biotechnol, Coll Life Sci & Oceanog, Shenzhen, Peoples R China;

Duke Univ, Dept Phys, Durham, NC 27706 USA;

Shenzhen Univ, Coll Optoelect Engn, Shenzhen, Peoples R China;

Duke Univ, Fitzpatrick Inst Photon, Durham, NC USA|Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA;

Shenzhen Univ, Longhua Innovat Inst Biotechnol, Coll Life Sci & Oceanog, Shenzhen, Peoples R China;

Duke Univ, Dept Biol, Durham, NC 27708 USA;

Duke Univ, Dept Biol, Durham, NC 27708 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Plant cell-surface GIPC sphingolipids sense salt to trigger Ca~(2+) influx [J] . Jiang Zhonghao, Zhou Xiaoping, Tao Ming, Nature . 2019,第7769期

机译：植物细胞表面GIPC鞘脂素感测盐以触发Ca〜（2+）涌入
2. Polyamine triggering of exocytosis in Paramecium involves an extracellular Ca(2+)/(polyvalent cation)-sensing receptor, subplasmalemmal Ca-store mobilization and store-operated Ca(2+)-influx via unspecific cation channels. [J] . Klauke N, Blanchard M, Plattner H The Journal of Membrane Biology: An International Journal for Studies on the Structure, Function & Genesis of Biomembranes . 2000,第2期

机译：草履虫中胞吐作用的多胺触发涉及细胞外Ca（2 +）/（多价阳离子）感应受体，浆膜下Ca存储动员和通过非特异性阳离子通道进行存储操作的Ca（2+）流入。
3. PA1b, a plant peptide, induces intracellular [Ca~(2+)] increase via Ca~(2+) influx through the L-type Ca~(2+) channel and triggers secretion in pancreatic β cells [J] . HU ZhiTao, DUN XinPeng, ZHANG Ming, Science in China. Series C, Life sciences . 2007,第3期

机译：植物肽PA1b通过经由L型Ca〜（2+）通道的Ca〜（2+）流入诱导细胞内[Ca〜（2+）]的增加，并触发胰腺β细胞的分泌
4. MECHANOTRANSDUCTIVE EFFECTS OF ACOUSTIC RADIATION FORCE ON OSTEOBLASTIC PRIMARY CILIUM, CYTOSKELETON AND CA~(2+) INFLUX [C] . QIN YX, ZHANG S, CHENG J ASME summer bioengineering conference;SBC2012 . 2012

机译：声辐射力对成骨细胞原代细胞，细胞骨架和CA〜（2+）内流的力学传导效应
5. Escherichia coli O157:H7 cell surface moieties trigger plant defense response influencing survival of that pathogen on plants. [D] . Seo, Seung-Wook. 2013

机译：大肠杆菌O157：H7细胞表面部分触发植物防御反应，影响该病原体在植物上的存活。
6. Biophysical analysis of the plant-specific GIPC sphingolipids reveals multiple modes of membrane regulation [O] . Adiilah Mamode Cassim, Yotam Navon, Yu Gao, 2021

机译：植物特异性GIPC鞘脂的生物物理分析显示出多种膜调节模式
7. Mutations of the ca(2+)-sensing stromal interaction molecule stim1 regulate ca(2+) influx by altered oligomerization of stim1 and by destabilization of the ca(2+) channel orai1 [O] . Kilch, T., Alansary, D., Peglow, M., 2013

机译：ca（2 +） - 感应基质相互作用分子刺激物的突变通过改变刺激物的寡聚化和ca（2+）通道的不稳定来调节ca（2+）流入。

Plant cell-surface GIPC sphingolipids sense salt to trigger Ca~(2+) influx

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