Organization and regulation of gene transcription

Cramer Patrick

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Organization and regulation of gene transcription

机译：基因转录的组织与调控

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The regulated transcription of genes determines cell identity and function. Recent structural studies have elucidated mechanisms that govern the regulation of transcription by RNA polymerases during the initiation and elongation phases. Microscopy studies have revealed that transcription involves the condensation of factors in the cell nucleus. A model is emerging for the transcription of protein-coding genes in which distinct transient condensates form at gene promoters and in gene bodies to concentrate the factors required for transcription initiation and elongation, respectively. The transcribing enzyme RNA polymerase II may shuttle between these condensates in a phosphorylation-dependent manner. Molecular principles are being defined that rationalize transcriptional organization and regulation, and that will guide future investigations.

机译：基因的调控转录决定了细胞的身份和功能。最近的结构研究阐明了在起始和延伸阶段控制RNA聚合酶转录调控的机制。显微镜研究表明，转录涉及细胞核中因子的凝聚。正在出现一种用于蛋白质编码基因转录的模型，其中在基因启动子和基因体中形成不同的瞬时冷凝物，以分别集中转录起始和延伸所需的因子。转录酶RNA聚合酶II可以磷酸化依赖性方式在这些缩合物之间穿梭。正在定义合理化转录组织和调控的分子原理，并将指导未来的研究。

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来源
《Nature》 |2019年第7772期|45-54|共10页
作者
Cramer Patrick;
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Max Planck Inst Biophys Chem Dept Mol Biol Gottingen Germany;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. Cohesin mediates Esco2-dependent transcriptional regulation in a zebrafish regenerating fin model of Roberts Syndrome Cohesin mediates Esco2-dependent transcriptional regulation in a zebrafish regenerating fin model of Roberts Syndrome Cohesin mediates Esco2-dependent transcriptional regulation in a zebrafish regenerating fin model of Roberts Syndrome [J] . Rajeswari Banerji, Robert V. Skibbens, M. Kathryn Iovine Biology Open . 2017,第12期

机译：Cohesin介导罗伯茨综合征斑马鱼再生鳍模型中Esco2依赖性转录调控Cohesin介导罗伯茨综合征斑马鱼再生鳍模型中Esco2依赖性转录调控Cohesin介导Roberts综合征斑马鱼再生鳍模型中Esco2依赖性转录调控。
2. The expression of the T-box selector gene midline in the leg imaginal disc is controlled by both transcriptional regulation and cell lineage The expression of the T-box selector gene midline in the leg imaginal disc is controlled by both transcriptional regulation and cell lineage The expression of the T-box selector gene midline in the leg imaginal disc is controlled by both transcriptional regulation and cell lineage [J] . Pia C. Svendsen, William J. Brook, Jae-Ryeon Ryu Biology Open . 2015,第12期

机译：T-box选择基因中线在腿部影像盘中的表达受转录调控和细胞谱系控制T-box选择基因中线在腿部影像盘中的表达受转录调控和细胞谱系控制腿想象盘中T-box选择基因中线的表达受转录调控和细胞谱系的控制
3. IL-2-dependent expression of genes involved in cytoskeleton organization, oncogene regulation, and transcriptional control. [J] . Herblot S, Chastagner P, Samady L, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第6期

机译：与细胞骨架组织，致癌基因调节和转录控制有关的基因的IL-2依赖性表达。
4. A framework for integrative analysis of transcriptional and post-transcriptional gene regulation [C] . Ogul H., Ozcan G.S. 7th International Conference on Application of Information and Communication Technologies . 2013

机译：转录和转录后基因调控的综合分析框架
5. Transcriptional regulation of C. elegans excretory cell-expressed genes by the POU homeobox transcription factor CEH-6. [D] . Mah, Allan. 2009

机译：POU同源盒转录因子CEH-6对秀丽隐杆线虫分泌细胞表达基因的转录调节。
6. Dynamic nature of transcriptional regulation of nuclear receptor target genes in the context of chromatin organization [O] . Sami Väisänen, Juha Matilainen, Carsten Carlberg 2011

机译：染色质组织背景下核受体靶基因转录调控的动态性质
7. An integrative bioinformatics approach for analyses of multi-level transcriptional regulation and three-dimensional organization in the epidermis and skin appendages. Exploring genomic transcriptional profiles of the distinct stages of hair follicle and sweat gland development and analyses of mechanism integrating the transcriptional regulation, linear and high-order genome organization within epidermal differentiation complex in keratinocytes. [O] . Poterlowicz K. 2013

机译：一种综合生物信息学方法，用于分析表皮和皮肤附件的多级转录调控和三维组织。探索毛囊和汗腺发育不同阶段的基因组转录概况，并分析角质形成细胞表皮分化复合物中转录调控，线性和高级基因组组织的整合机制。

Organization and regulation of gene transcription

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