• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
【24h】

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

机译：PIEZO1的周期性力机械传感对于先天免疫至关重要

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Direct recognition of invading pathogens by innate immune cells is a critical driver of the inflammatory response. However, cells of the innate immune system can also sense their local microenvironment and respond to physiological fluctuations in temperature, pH, oxygen and nutrient availability, which are altered during inflammation. Although cells of the immune system experience force and pressure throughout their life cycle, little is known about how these mechanical processes regulate the immune response. Here we show that cyclical hydrostatic pressure, similar to that experienced by immune cells in the lung, initiates an inflammatory response via the mechanically activated ion channel PIEZO1. Mice lacking PIEZO1 in innate immune cells showed ablated pulmonary inflammation in the context of bacterial infection or fibrotic autoinflammation. Our results reveal an environmental sensory axis that stimulates innate immune cells to mount an inflammatory response, and demonstrate a physiological role for PIEZO1 and mechanosensation in immunity.
机译：先天性免疫细胞对入侵病原体的直接识别是炎症反应的关键驱动因素。但是，先天免疫系统的细胞还可以感知其局部微环境，并对温度，pH，氧气和营养物质的利用率在炎症过程中发生变化的生理波动做出反应。尽管免疫系统的细胞在其整个生命周期中都会经历力和压力，但对于这些机械过程如何调节免疫反应的了解却很少。在这里，我们显示出周期性的静水压力，类似于肺中免疫细胞所经历的静水压力，通过机械激活的离子通道PIEZO1引发炎症反应。先天免疫细胞中缺乏PIEZO1的小鼠在细菌感染或纤维化自发炎症的情况下表现出肺部炎症消融。我们的研究结果揭示了一个环境感觉轴，该轴可刺激先天免疫细胞引发炎症反应，并证明PIEZO1和机械感觉在免疫中的生理作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号