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A reference map of the human binary protein interactome

机译：人二元蛋白质相互作用组的参考图

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摘要

Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships~(1,2). Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome~(3), transcriptome~(4)and proteome~(5)data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes.
机译：对细胞组织和基因组功能的全球见解需要对介导基因型-表型关系的相互作用组网络的全面了解[1,2]。在这里，我们介绍了人类二进制蛋白质相互作用或“ HuRI”的人类“全部”参考相互作用组图。与大约53,000种蛋白质-蛋白质相互作用相比，HuRI具有的此类相互作用大约是小规模研究中高质量策划的相互作用的四倍。 HuRI与基因组〜（3），转录组〜（4）和蛋白质组〜（5）数据的整合使细胞功能能够在大多数生理或病理细胞环境中进行研究。我们证明了HuRI在鉴定蛋白质间相互作用的特定亚细胞作用中的效用。推断的组织特异性网络揭示了形成细胞背景特异性功能的一般原理，并阐明了可能是孟德尔疾病组织特异性表型基础的潜在分子机制。 HuRI是一个系统的全蛋白质组参考，将基因组变异与表型结果联系起来。

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    《Nature》 |2020年第7803期|402-408|共7页
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    Center for Cancer Systems Biology (CCSB) Dana-Farber Cancer Institute|Department of Genetics Blavatnik Institute Harvard Medical School|Department of Cancer Biology Dana-Farber Cancer Institute;

    Center for Cancer Systems Biology (CCSB) Dana-Farber Cancer Institute|The Donnelly Centre University of Toronto|Department of Molecular Genetics University of Toronto|Lunenfeld-Tanenbaum Research Institute (LTRI) Sinai Health System;

    Cancer Research Center (CiC-IBMCC CSIC/USAL) Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca (USAL)|Institute for Biomedical Research of Salamanca (IBSAL);

    The Research Institute of the McGill University Health Centre (RI-MUHC);

    Department of Cell and Systems Biology University of Toronto;

    Center for Cancer Systems Biology (CCSB) Dana-Farber Cancer Institute|Department of Genetics Blavatnik Institute Harvard Medical School|Department of Cancer Biology Dana-Farber Cancer Institute|Molecular Biology of Diseases Groupe Interdisciplinaire de Génomique Appliquée (GIGA) and Laboratory of Viral Interactomes University of Liège;

    Center for Cancer Systems Biology (CCSB) Dana-Farber Cancer Institute|Network Science Institute Northeastern University|Wigner Research Centre for Physics Institute for Solid State Physics and Optics;

    Center for Medical Biotechnology Vlaams Instituut voor Biotechnologie (VIB)|Cytokine Receptor Laboratory (CRL) Department of Biomolecular Medicine Faculty of Medicine and Health Sciences Ghent University;

    The Donnelly Centre University of Toronto|Department of Molecular Genetics University of Toronto|Department of Computer Science University of Toronto;

    Center for Cancer Systems Biology (CCSB) Dana-Farber Cancer Institute|The Donnelly Centre University of Toronto|Department of Molecular Genetics University of Toronto|Lunenfeld-Tanenbaum Research Institute (LTRI) Sinai Health System|seqWell;

    Institute for Research in Biomedicine (IRB Barcelona) The Barcelona Institute for Science and Technology;

    Department of Clinical Biochemistry and Pharmacology Faculty of Health Sciences Ben-Gurion University of the Negev|National Institute for Biotechnology in the Negev (NIBN) Ben-Gurion University of the Negev;

    Department of Genetics Blavatnik Institute Harvard Medical School|Department of Cancer Biology Dana-Farber Cancer Institute;

    Cancer Research UK (CRUK) Cambridge Institute University of Cambridge;

    Department of Pharmaceutical Sciences University of Perugia|Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati" (IZSUM);

    Département de Virologie Unité de Génétique Moléculaire des Virus à ARN (GMVR) Institut Pasteur|Université Paris Diderot;

    Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute|Department of Biostatistics Harvard School of Public Health|Department of Biostatistics Product Development Genentech Inc;

    Center for Cancer Systems Biology (CCSB) Dana-Farber Cancer Institute|The Donnelly Centre University of Toronto|Department of Molecular Genetics University of Toronto|Lunenfeld-Tanenbaum Research Institute (LTRI) Sinai Health System|Department of Computer Science University of Toronto;

    Molecular Biology of Diseases Groupe Interdisciplinaire de Génomique Appliquée (GIGA) and Laboratory of Viral Interactomes University of Liège;

    The Donnelly Centre University of Toronto;

    Center for Cancer Systems Biology (CCSB) Dana-Farber Cancer Institute|Department of Bioengineering McGill University;

    Center for Cancer Systems Biology (CCSB) Dana-Farber Cancer Institute|Department of Genetics Blavatnik Institute Harvard Medical School|Department of Cancer Biology Dana-Farber Cancer Institute|Department of Biological Sciences Wright State University;

    Institute for Research in Biomedicine (IRB Barcelona) The Barcelona Institute for Science and Technology|Institució Catalana de Recerca i Estudis Avançats (ICREA);

    Center for Cancer Systems Biology (CCSB) Dana-Farber Cancer Institute|Department of Genetics Blavatnik Institute Harvard Medical School;

    Center for Cancer Systems Biology (CCSB) Dana-Farber Cancer Institute|The Donnelly Centre University of Toronto|Department of Molecular Genetics University of Toronto|Lunenfeld-Tanenbaum Research Institute (LTRI) Sinai Health System|Department of Computer Science University of Toronto|Canadian Institute for Advanced Research (CIFAR);

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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