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首页> 外文期刊>Nature >Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis
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Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis

机译：通过Calsyntenin3β-S100B轴线支配热脂肪组织

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摘要

The sympathetic nervous system drives brown and beige adipocyte thermogenesis through the release of noradrenaline from local axons. However, the molecular basis of higher levels of sympathetic innervation of thermogenic fat, compared to white fat, has remained unknown. Here we show that thermogenic adipocytes express a previously unknown, mammal-specific protein of the endoplasmic reticuhim that we term calsyntenin 3 beta. Genetic loss or gain of expression of calsyntenin 3 beta in adipocytes reduces or enhances functional sympathetic innervation, respectively, in adipose tissue. Ablation of calsyntenin 3 beta predisposes mice on a high-fat diet to obesity. Mechanistically, calsyntenin 3 beta promotes endoplasmic-reticulum localization and secretion of S100b-a protein that lacks a signal peptide-from brown adipocytes. S100b stimulates neurite outgrowth from sympathetic neurons in vitro. A deficiency of S100b phenocopies deficiency of calsyntenin 3 beta, and forced expression of S100b in brown adipocytes rescues the defective sympathetic innervation that is caused by ablation of calsyntenin 3 beta. Our data reveal a mammal-specific mechanism of communication between thermogenic adipocytes and sympathetic neurons.
机译：交感神经系统通过从局部轴突释放去甲肾上腺素来驱动棕色和米色adipocyte的热生成。然而，与白脂肪相比，热脂肪较高的分子基础，相比白脂肪仍然未知。在这里，我们表明，热脂肪细胞表达先前未知的内质视网膜的哺乳动物特异性蛋白质，即我们术语Calsyntenin 3β。在脂肪细胞中，Calsyntenin3β的遗传损失或表达的增益分别在脂肪组织中减少或增强功能性交感神经内化。 Calsyntenin 3β的消融促使小鼠高脂肪饮食令人肥胖。机械上，Calsyntenin3β促进内质 - 网状定位和分泌S100B-A蛋白质，其缺乏信号肽 - 来自棕色脂肪细胞。 S100B在体外刺激来自交感神经元的神经突生长。缺乏Calsyntenin3β的S100B缺陷缺乏，并且棕色脂肪细胞中的S100b的强制表达抵押了由Calsyntenin3β的消融引起的缺陷的交感神经检查。我们的数据揭示了热生成脂肪细胞和交感神经元之间的哺乳动物特定机制。

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  • 来源
    《Nature》 |2019年第7755期|229-235|共7页
  • 作者

    Zeng Xing; Ye Mengchen; Resch Jon M.; Jedrychowski Mark P.; Hu Bo; Lowell Bradford B.; Ginty David D.; Spiegelman Bruce M.;

  • 作者单位

    Dana Farber Canc Inst Dept Canc Biol Boston MA 02115 USA|Harvard Med Sch Dept Cell Biol Boston MA 02115 USA;

    Harvard Med Sch Dept Neurobiol Howard Hughes Med Inst Boston MA 02115 USA;

    Harvard Med Sch Div Endocrinol Diabet & Metab Dept Med Beth Israel Deaconess Med Ctr Boston MA 02115 USA;

    Dana Farber Canc Inst Dept Canc Biol Boston MA 02115 USA|Harvard Med Sch Dept Cell Biol Boston MA 02115 USA;

    Dana Farber Canc Inst Dept Canc Biol Boston MA 02115 USA|Harvard Med Sch Dept Cell Biol Boston MA 02115 USA;

    Harvard Med Sch Div Endocrinol Diabet & Metab Dept Med Beth Israel Deaconess Med Ctr Boston MA 02115 USA|Harvard Med Sch Program Neurosci Boston MA 02115 USA;

    Harvard Med Sch Dept Neurobiol Howard Hughes Med Inst Boston MA 02115 USA;

    Dana Farber Canc Inst Dept Canc Biol Boston MA 02115 USA|Harvard Med Sch Dept Cell Biol Boston MA 02115 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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