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Perspectives on ENCODE

机译：编码的透视图

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摘要

The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidatecis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression(1). The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.
机译：DNA元素（编码）项目的联合血症于2003年推出，长期目标是在人类基因组中开发综合功能元素地图。这些包括基因，与基因调节相关的生物化学区域（例如，转录因子结合位点，开染蛋白和组蛋白标记）和转录同种型。该标记用作念珠菌调节元素（Curres）的位点，其可用于调节基因表达（1）的功能作用。该项目已经扩展到模型生物，特别是鼠标。在编码的第三阶段，分别为人和小鼠产生了近百万且超过300,000个CCRE注释，这些注释为科学界提供了有价值的资源。该作者总结了编码项目的历史，成就编码1和编码2，以及如何在编码3中生成和分析的新数据补充前一阶段。

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  • 来源
    《Nature》 |2020年第7818期|693-698|共6页
  • 作者

    Snyder Michael P.; Gingeras Thomas R.; Moore Jill E.; Weng Zhiping; Gerstein Mark B.; Ren Bing; Hardison Ross C.; Stamatoyannopoulos John A.; Graveley Brenton R.; Feingold Elise A.; Pazin Michael J.; Pagan Michael; Gilchrist Daniel A.; Hitz Benjamin C.; Cherry J. Michael; Bernstein Bradley E.; Mendenhall Eric M.; Zerbino Daniel R.; Frankish Adam; Flicek Paul; Myers Richard M.;

  • 作者单位

    Stanford Univ Sch Med Dept Genet Palo Alto CA 94304 USA|Stanford Sch Med Cardiovasc Inst Stanford CA 94305 USA;

    Cold Spring Harbor Lab Funct Genom POB 100 Cold Spring Harbor NY 11724 USA;

    Univ Massachusetts Sch Med Program Bioinformat & Integrat Biol Worcester MA USA;

    Univ Massachusetts Sch Med Program Bioinformat & Integrat Biol Worcester MA USA|Tongji Univ Shanghai Pulm Hosp Sch Life Sci & Technol Dept Thorac Surg Clin Translat Res Ctr Shanghai Peoples R China|Boston Univ Bioinformat Program Boston MA 02215 USA;

    Yale Univ New Haven CT USA;

    Univ Calif San Diego Ludwig Inst Canc Res San Diego CA 92103 USA|Univ Calif San Diego Ctr Epigen San Diego CA 92103 USA;

    Penn State Univ Dept Biochem & Mol Biol University Pk PA 16802 USA;

    Altius Inst Biomed Sci Seattle WA USA|Univ Washington Dept Genome Sci Seattle WA 98195 USA|Univ Washington Dept Med Seattle WA USA;

    UConn Hlth Inst Syst Genom Dept Genet & Genome Sci Farmington CT USA;

    NHGRI NIH Bethesda MD 20892 USA;

    NHGRI NIH Bethesda MD 20892 USA;

    NHGRI NIH Bethesda MD 20892 USA;

    NHGRI NIH Bethesda MD 20892 USA;

    Stanford Univ Sch Med Dept Genet Palo Alto CA 94304 USA;

    Stanford Univ Sch Med Dept Genet Palo Alto CA 94304 USA;

    Massachusetts Gen Hosp Broad Inst Boston MA 02114 USA|Massachusetts Gen Hosp Dept Pathol Boston MA 02114 USA|Harvard Med Sch Boston MA 02115 USA;

    Univ Alabama Biol Sci Huntsville AL 35899 USA|HudsonAlpha Inst Biotechnol Huntsville AL USA;

    European Bioinformat Inst European Mol Biol Lab Wellcome Genome Campus Cambridge England;

    European Bioinformat Inst European Mol Biol Lab Wellcome Genome Campus Cambridge England;

    European Bioinformat Inst European Mol Biol Lab Wellcome Genome Campus Cambridge England;

    HudsonAlpha Inst Biotechnol Huntsville AL USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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