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Innovations present in the primate interneuron repertoire

机译：灵长类动物中间人曲目中的创新

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摘要

Primates and rodents, which descended from a common ancestor around 90 million years ago(1), exhibit profound differences in behaviour and cognitive capacity; the cellular basis for these differences is unknown. Here we use single-nucleus RNA sequencing to profile RNA expression in 188,776 individual interneurons across homologous brain regions from three primates (human, macaque and marmoset), a rodent (mouse) and a weasel (ferret). Homologous interneuron types-which were readily identified by their RNA-expression patterns-varied in abundance and RNA expression among ferrets, mice and primates, but varied less among primates. Only a modest fraction of the genes identified as 'markers' of specific interneuron subtypes in any one species had this property in another species. In the primate neocortex, dozens of genes showed spatial expression gradients among interneurons of the same type, which suggests that regional variation in cortical contexts shapes the RNA expression patterns of adult neocortical interneurons. We found that an interneuron type that was previously associated with the mouse hippocampus-the 'ivy cell', which has neurogliaform characteristics-has become abundant across the neocortex of humans, macaques and marmosets but not mice or ferrets. We also found a notable subcortical innovation: an abundant striatal interneuron type in primates that had no molecularly homologous counterpart in mice or ferrets. These interneurons expressed a unique combination of genes that encode transcription factors, receptors and neuropeptides and constituted around 30% of striatal interneurons in marmosets and humans.Single-nucleus RNA-sequencing analyses of brain from humans, macaques, marmosets, mice and ferrets reveal diverse ways that interneuron populations have changed during evolution.
机译：灵长类动物和啮齿动物，其中从9000万年前从共同的祖先下降（1），表现出行为和认知能力的深刻差异;这些差异的细胞基础是未知的。在这里，我们使用单核RNA测序在188,776个单独的脑区中的单个脑区中的单个细胞核表达，从三个灵长类动物（人，猕猴和marmoset），啮齿动物（小鼠）和黄鼠狼（雪貂）中的同源脑区。通过其RNA表达模式容易地鉴定在雪貂，小鼠和灵长类动物中的RNA表达模式中的含有RNA表达模式，但在灵长造物中变得不那么多种。在任何一种物种中仅鉴定为“标记物”的基因的一种基因，在另一种物种中具有这种性质。在灵长类动物的Neocortex中，数十种基因显示出相同类型的中间核之间的空间表达梯度，这表明皮质背景下的区域变异是成年淋新异性核的RNA表达模式。我们发现先前与小鼠海马 - “常春藤细胞”相关联的内核类型，其具有神经胶质表现特征 - 在人类，猕猴和Marmosets的Neocortex上变得丰富，但不是小鼠或雪貂。我们还发现了一个值得注意的皮质创新：在灵长类动物中，在小鼠或雪铁中没有分子同源对应物的灵感丰富的纹状体型。这些型细胞表达了编码转录因子，受体和神经肽的基因的独特组合，并构成了Marmosets和人类的纹状体间的30％。脑从人类，猕猴，MICE，小鼠和雪貂的脑中脑序列分析揭示多样化在进化过程中，Interneuron人群发生变化的方式。

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  • 来源
    《Nature》 |2020年第7828期|262-269|共8页
  • 作者

    Krienen Fenna M.; Goldman Melissa; Zhang Qiangge; C. H. del Rosario Ricardo; Florio Marta; Machold Robert; Saunders Arpiar; Levandowski Kirsten; Zaniewski Heather; Schuman Benjamin; Wu Carolyn; Lutservitz Alyssa; Mullally Christopher D.; Reed Nora; Bien Elizabeth; Bortolin Laura; Fernandez-Otero Marian; Lin Jessica D.; Wysoker Alec; Nemesh James; Kulp David; Burns Monika; Tkachev Victor; Smith Richard; Walsh Christopher A.; Dimidschstein Jordane; Rudy Bernardo; S. Kean Leslie; Berretta Sabina; Fishell Gord; Feng Guoping; McCarroll Steven A.;

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    Harvard Med Sch Dept Genet Boston MA 02115 USA|Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    Harvard Med Sch Dept Genet Boston MA 02115 USA|Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA|MIT Dept Brain & Cognit Sci McGovern Inst Brain Res E25-618 Cambridge MA 02139 USA;

    Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    Harvard Med Sch Dept Genet Boston MA 02115 USA|Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    NYU Langone Med Ctr Neurosci Inst New York NY USA;

    Harvard Med Sch Dept Genet Boston MA 02115 USA|Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA|MIT Dept Brain & Cognit Sci McGovern Inst Brain Res E25-618 Cambridge MA 02139 USA;

    Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA|MIT Dept Brain & Cognit Sci McGovern Inst Brain Res E25-618 Cambridge MA 02139 USA;

    NYU Langone Med Ctr Neurosci Inst New York NY USA;

    MIT Dept Brain & Cognit Sci McGovern Inst Brain Res E25-618 Cambridge MA 02139 USA;

    Harvard Med Sch Dept Genet Boston MA 02115 USA|Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    Harvard Med Sch Dept Genet Boston MA 02115 USA|Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    Harvard Med Sch Dept Genet Boston MA 02115 USA|Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    Harvard Med Sch Dept Genet Boston MA 02115 USA|Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    Harvard Med Sch Dept Genet Boston MA 02115 USA|Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA|MIT Dept Biol Engn Div Comparat Med 77 Massachusetts Ave Cambridge MA 02139 USA;

    Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    MIT Dept Biol Engn Div Comparat Med 77 Massachusetts Ave Cambridge MA 02139 USA;

    Boston Childrens Hosp Div Hematol Oncol Boston MA USA|Dana Farber Canc Inst Dept Pediat Oncol Boston MA 02115 USA|Harvard Med Sch Dept Pediat Boston MA 02115 USA;

    Boston Childrens Hosp Dept Pediat Boston MA USA|Boston Childrens Hosp Div Genet & Genom Boston MA USA;

    Boston Childrens Hosp Dept Pediat Boston MA USA|Boston Childrens Hosp Div Genet & Genom Boston MA USA;

    Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

    NYU Langone Med Ctr Neurosci Inst New York NY USA|NYU Sch Med Dept Anesthesiol Perioperat Care & Pain Med New York NY USA;

    Boston Childrens Hosp Div Hematol Oncol Boston MA USA|Dana Farber Canc Inst Dept Pediat Oncol Boston MA 02115 USA|Harvard Med Sch Dept Pediat Boston MA 02115 USA;

    MIT Dept Biol Engn Div Comparat Med 77 Massachusetts Ave Cambridge MA 02139 USA|McLean Hosp 115 Mill St Belmont MA 02178 USA|Harvard Med Sch Dept Psychiat Boston MA 02115 USA;

    Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA|Harvard Med Sch Program Neurosci Boston MA 02115 USA;

    Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA|MIT Dept Brain & Cognit Sci McGovern Inst Brain Res E25-618 Cambridge MA 02139 USA;

    Harvard Med Sch Dept Genet Boston MA 02115 USA|Broad Inst MIT & Harvard Stanley Ctr Psychiat Res Cambridge MA 02142 USA;

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