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Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo'

机译：抑制了vo'意大利自治市的SARS-COV-2爆发

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摘要

On 21 February 2020, a resident of the municipality of Vo', a small town near Padua (Italy), died of pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection(1). This was the first coronavirus disease 19 (COVID-19)-related death detected in Italy since the detection of SARS-CoV-2 in the Chinese city of Wuhan, Hubei province(2) . In response, the regional authorities imposed the lockdown of the whole municipality for 14 days(3). Here we collected information on the demography, clinical presentation, hospitalization, contact network and the presence of SARS-CoV-2 infection in nasopharyngeal swabs for 85.9% and 71.5% of the population of Vo' at two consecutive time points. From the first survey, which was conducted around the time the town lockdown started, we found a prevalence of infection of 2.6% (95% confidence interval (CI): 2.1-3.3%). From the second survey, which was conducted at the end of the lockdown, we found a prevalence of 1.2% (95% CI: 0.8-1.8%). Notably, 42.5% (95% CI: 31.5-54.6%) of the confirmed SARS-CoV-2 infections detected across the two surveys were asymptomatic (that is, did not have symptoms at the time of swab testing and did not develop symptoms afterwards). The mean serial interval was 7.2 days (95% CI: 5.9-9.6). We found no statistically significant difference in the viral load of symptomatic versus asymptomatic infections (P = 0.62 and 0.74 for E and RdRp genes, respectively, exact Wilcoxon-Mann-Whitney test). This study sheds light on the frequency of asymptomatic SARS-CoV-2 infection, their infectivity (as measured by the viral load) and provides insights into its transmission dynamics and the efficacy of the implemented control measures.
机译：2020年2月21日，由于严重的急性呼吸综合征冠状病毒2（SARS-COV-2）感染（1），Died of Padua附近的小镇vo'vo'居民。这是在意大利检测到湖北省武汉市的SARS-COV-2（2）以来，在意大利检测到的第一个冠状病毒疾病19（Covid-19）的死亡。作为回应，区域当局强制整个市政府锁定14天（3）。在这里，我们收集了有关人口统计学，临床介绍，住院，接触网络的信息，并在连续两个时间点的鼻咽拭子中的SARS-COV-2感染的SARS-COV-2感染85.9％和71.5％。从第一次调查开始，在城镇锁定开始时进行，我们发现感染的患病率为2.6％（95％置信区间（CI）：2.1-3.3％）。从第二次调查开始，在锁定结束时进行，我们发现患病率为1.2％（95％CI：0.8-1.8％）。特别是，在两次调查中检测到的42.5％（95％CI：31.5-54.6％）确认的SAR-COV-2感染是无症状的（即，在拭子测试时没有症状，并且之后没有发展症状）。平均序间隔为7.2天（95％CI：5.9-9.6）。我们发现症状与无症状感染的病毒载量没有统计学显着差异（P = 0.62和0.74，分别用于E和RDRP基因，精确的Wilcoxon-Mann-Whitney测试）。本研究揭示了无症状SARS-COV-2感染的频率，它们的感染性（按病毒载量测量），并提供了进入其传输动态的见解和实施的控制措施的功效。

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