• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Keratins are asymmetrically inherited fate determinants in the mammalian embryo
【24h】

Keratins are asymmetrically inherited fate determinants in the mammalian embryo

机译：角蛋白是哺乳动物胚胎中的不对称继承的命运决定因素

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To implant in the uterus, the mammalian embryo first specifies two cell lineages: the pluripotent inner cell mass that forms the fetus, and the outer trophectoderm layer that forms the placenta(1). In many organisms, asymmetrically inherited fate determinants drive lineage specification(2), but this is not thought to be the case during early mammalian development. Here we show that intermediate filaments assembled by keratins function as asymmetrically inherited fate determinants in the mammalian embryo. Unlike F-actin or microtubules, keratins are the first major components of the cytoskeleton that display prominent cell-to-cell variability, triggered by heterogeneities in the BAF chromatin-remodelling complex. Live-embryo imaging shows that keratins become asymmetrically inherited by outer daughter cells during cell division, where they stabilize the cortex to promote apical polarization and YAP-dependent expression of CDX2, thereby specifying the first trophectoderm cells of the embryo. Together, our data reveal a mechanism by which cell-to-cell heterogeneities that appear before the segregation of the trophectoderm and the inner cell mass influence lineage fate, via differential keratin regulation, and identify an early function for intermediate filaments in development.Keratins are determinants of cell fate during mammalian embryogenesis, and are distributed asymmetrically between daughter cells during cell division.
机译：为了植入子宫，哺乳动物胚胎首先指定两个细胞谱系：形成胎儿的多能内细胞质量，以及形成胎盘（1）的外促肾小体层。在许多生物中，非对称继承的命运决定因素驱动谱系规范（2），但在早期哺乳动物的发展中，这并未被认为是这种情况。在这里，我们表明，由角蛋白酶组装的中间细丝函数在哺乳动物胚胎中的不对称继承的命运决定簇。与F-肌动蛋白或微管不同，角蛋白是细胞骨架的第一个主要组成部分，其显示突出的细胞 - 细胞变异性，由BAF染色质重塑复合物中的异质引发。活胚成像表明，角蛋白在细胞分裂期间由外女性细胞变得不对称继承，在那里它们稳定皮质以促进CDX2的顶端偏振和依赖依赖性表达，从而指定胚胎的第一晶体胚胎细胞。我们的数据一起揭示了一种机制，通过差动角蛋白调节，在肾小管胚胎和内部电池肿块的分离之前出现的细胞对细胞异质性，并通过差分角蛋白调节鉴定发育中中间细丝的早期功能。Keratins是哺乳动物胚胎发生过程中的细胞命运的决定因素，在细胞分裂期间在子细胞之间不对称地分布。

著录项

  • 来源
    《Nature》 |2020年第7825期|404-409|共6页
  • 作者

    Lim Hui Yi Grace; Alvarez Yanina D.; Gasnier Maxime; Wang Yiming; Tetlak Piotr; Bissiere Stephanie; Wang Hongmei; Biro Mate; Plachta Nicolas;

  • 作者单位

    ASTAR Inst Mol & Cell Biol Singapore Singapore;

    ASTAR Inst Mol & Cell Biol Singapore Singapore;

    ASTAR Inst Mol & Cell Biol Singapore Singapore;

    Chinese Acad Sci Inst Zool State Key Lab Stem Cell & Reprod Biol Beijing Peoples R China;

    ASTAR Inst Mol & Cell Biol Singapore Singapore;

    ASTAR Inst Mol & Cell Biol Singapore Singapore;

    Chinese Acad Sci Inst Zool State Key Lab Stem Cell & Reprod Biol Beijing Peoples R China;

    Univ New South Wales Sch Med Sci Single Mol Sci Node EMBL Australia Sydney NSW Australia;

    ASTAR Inst Mol & Cell Biol Singapore Singapore|Univ Penn Perelman Sch Med Dept Cell & Dev Biol Philadelphia PA 19104 USA|Univ Penn Perelman Sch Med Inst Regenerat Med Philadelphia PA 19104 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号