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Origin and elaboration of a major evolutionary transition in individuality

机译：对个性的主要进化过渡的起源和阐述

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摘要

Obligate endosymbiosis, in which distantly related species integrate to form a single replicating individual, represents a major evolutionary transition in individuality(1-3). Although such transitions are thought to increase biological complexity(1,2,4-6), the evolutionary and developmental steps that lead to integration remain poorly understood. Here we show that obligate endosymbiosis between the bacteriaBlochmanniaand the hyperdiverse ant tribe Camponotini(7-11)originated and also elaborated through radical alterations in embryonic development, as compared to other insects. The Hox genesAbdominal A(abdA) andUltrabithorax(Ubx)-which, in arthropods, normally function to differentiate abdominal and thoracic segments after they form-were rewired to also regulate germline genes early in development. Consequently, the mRNAs and proteins of these Hox genes are expressed maternally and colocalize at a subcellular level with those of germline genes in the germplasm and three novel locations in the freshly laid egg.Blochmanniabacteria then selectively regulate these mRNAs and proteins to make each of these four locations functionally distinct, creating a system of coordinates in the embryo in which each location performs a different function to integrateBlochmanniainto the Camponotini. Finally, we show that the capacity to localize mRNAs and proteins to new locations in the embryo evolved before obligate endosymbiosis and was subsequently co-opted byBlochmanniaand Camponotini. This pre-existing molecular capacity converged with a pre-existing ecological mutualism(12,13)to facilitate both the horizontal transfer(10)and developmental integration ofBlochmanniainto Camponotini. Therefore, the convergence of pre-existing molecular capacities and ecological interactions-as well as the rewiring of highly conserved gene networks-may be a general feature that facilitates the origin and elaboration of major transitions in individuality.Obligate endosymbiosis between the bacteriaBlochmanniaand ants of the Camponotini tribe originated through co-option of pre-existing molecular capacities and rewiring of developmental gene regulatory networks.
机译：indosymbiosis，其中遥远相关的物种整合以形成单一的复制个体，代表个性的主要进化转变（1-3）。虽然这种转变被认为增加生物复杂性（1,2,4-6），但导致整合的进化和发育步骤仍然明白。在这里，我们表明，与其他昆虫相比，细菌Blochmannand之间的高层蚂蚁部落Camponotini（7-11）起源于胚胎发育的激进改变。 Hox Genesabnaminal A（ABDA）Andultrabithorax（UBX） - 在节肢动物中，通常在形成腹部和胸段中来分化腹部和胸段，以便在发育早期调节种系基因。因此，这些HOX基因的MRNA和蛋白质在亚细胞水平上表达潜水并与种质中的种质基因和新颖的鸡蛋中的三个新位置中的三种新位置。然后选择性地调节这些mRNA和蛋白质以使这些MRNA和蛋白质中的每一个在功能上独立的四个位置，在胚胎中创建一个坐标系统，其中每个位置对Camponotini ondentateBlochmanniainto执行不同的功能。最后，我们表明，在胚胎前症之前将MRNA和蛋白质定位MRNA和蛋白质的能力进化，随后与Blochmannand Camponotini共同选择。这种预先存在的分子容量融合了预先存在的生态互动（12,13），以促进Blocochmanniainto Camponotini的水平转移（10）和发育集成。因此，预先存在的分子容量和生态相互作用的收敛 - 以及高度保守的基因网络的重新加热 - 可能是一般的特征，促进各个性的主要转变的起源和培训。将内聚在细菌的细菌（Bractiablochmannand）之间的起源和培训Camponotini部落通过预先选择的预先选择的分子能力和发育基因监管网络的重新启动。

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  • 来源
    《Nature》 |2020年第7824期|239-244|共6页
  • 作者

    Rafiqi Ab. Matteen; Rajakumar Arjuna; Abouheif Ehab;

  • 作者单位

    McGill Univ Dept Biol Montreal PQ Canada|Bezmialem Vakif Univ Beykoz Inst Life Sci & Biotechnol Istanbul Turkey;

    McGill Univ Dept Biol Montreal PQ Canada;

    McGill Univ Dept Biol Montreal PQ Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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