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The gut microbiota is associated with immune cell dynamics in humans

机译：肠道微生物会与人类的免疫细胞动态相关

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摘要

Influence of the gut microbiome on the human immune system is revealed by systems analysis of vast clinical data from decades of electronic health records paired with massive longitudinal microbiome sequencing.The gut microbiota influences development(1-3) and homeostasis(4-7) of the mammalian immune system, and is associated with human inflammatory(8) and immune diseases(9,10) as well as responses to immunotherapy(11-14). Nevertheless, our understanding of how gut bacteria modulate the immune system remains limited, particularly in humans, where the difficulty of direct experimentation makes inference challenging. Here we study hundreds of hospitalized-and closely monitored-patients with cancer receiving haematopoietic cell transplantation as they recover from chemotherapy and stem-cell engraftment. This aggressive treatment causes large shifts in both circulatory immune cell and microbiota populations, enabling the relationships between the two to be studied simultaneously. Analysis of observed daily changes in circulating neutrophil, lymphocyte and monocyte counts and more than 10,000 longitudinal microbiota samples revealed consistent associations between gut bacteria and immune cell dynamics. High-resolution clinical metadata and Bayesian inference allowed us to compare the effects of bacterial genera in relation to those of immunomodulatory medications, revealing a considerable influence of the gut microbiota-together and over time-on systemic immune cell dynamics. Our analysis establishes and quantifies the link between the gut microbiota and the human immune system, with implications for microbiota-driven modulation of immunity.
机译：肠道微生物组对人类免疫系统的影响是通过与大规模纵向微生物组测序分配数十年的临床资料的巨大临床资料的系统分析。肠道微生物群地区的发育（1-3）和稳态（4-7）哺乳动物免疫系统，与人炎症（8）和免疫疾病（9,10）相关，以及对免疫疗法的反应（11-14）。尽管如此，我们对肠道细菌如何调节免疫系统的理解仍然有限，特别是在人类中，直接实验的难度使推理具有挑战性。在这里，我们研究了数百名住院和密切监测的患者，接受血液吞噬细胞移植的癌症，因为它们从化疗和干细胞植入中恢复。这种侵略性治疗导致循环免疫细胞和微生物群种群中大移位，从而能够同时研究两个待研究的关系。分析循环中性粒细胞，淋巴细胞和单核细胞计数的日常变化，淋巴细胞和单核细胞数量，超过10,000微生物样品揭示了肠道细菌和免疫细胞动力学之间的一致关联。高分辨率临床元数据和贝叶斯推断使我们能够比较细菌属与免疫调节药物相关的影响，揭示了肠道微生物群和过时的系统性免疫细胞动态的相当大的影响。我们的分析建立并量化了肠道微生物肿瘤和人类免疫系统之间的联系，具有对微生物群驱动的免疫调节的影响。

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  • 来源
    《Nature》 |2020年第7837期|303-307|共5页
  • 作者

    Schluter Jonas; Peled Jonathan U.; Taylor Bradford P.; Markey Kate A.; Smith Melody; Taur Ying; Niehus Rene; Staffas Anna; Dai Anqi; Fontana Emily; Amoretti Luigi A.; Wright Roberta J.; Morjaria Sejal; Fenelus Maly; Pessin Melissa S.; Chao Nelson J.; Lew Meagan; Bohannon Lauren; Bush Amy; Sung Anthony D.; Hohl Tobias M.; Perales Miguel-Angel; van den Brink Marcel R. M.; Xavier Joao B.;

  • 作者单位

    NYU Langone Hlth Inst Computat Med New York NY 10016 USA|Mem Sloan Kettering Canc Ctr Sloan Kettering Inst Computat & Syst Biol Program 1275 York Ave New York NY 10021 USA;

    Mem Sloan Kettering Canc Ctr Dept Med Adult Bone Marrow Transplantat Serv 1275 York Ave New York NY 10021 USA|Weill Cornell Med Coll New York NY USA;

    Mem Sloan Kettering Canc Ctr Sloan Kettering Inst Computat & Syst Biol Program 1275 York Ave New York NY 10021 USA;

    Mem Sloan Kettering Canc Ctr Dept Med Adult Bone Marrow Transplantat Serv 1275 York Ave New York NY 10021 USA|Weill Cornell Med Coll New York NY USA;

    Mem Sloan Kettering Canc Ctr Dept Med Adult Bone Marrow Transplantat Serv 1275 York Ave New York NY 10021 USA|Weill Cornell Med Coll New York NY USA;

    Sloan Kettering Inst Dept Med Infect Dis Serv New York NY USA|Sloan Kettering Inst Immunol Program New York NY USA;

    Harvard Univ TH Chan Sch Publ Hlth Boston MA 02115 USA;

    Univ Gothenburg Inst Biomed Dept Microbiol & Immunol Sahlgrenska Canc Ctr Gothenburg Sweden;

    Mem Sloan Kettering Canc Ctr Dept Med Adult Bone Marrow Transplantat Serv 1275 York Ave New York NY 10021 USA;

    Sloan Kettering Inst Dept Med Infect Dis Serv New York NY USA|Sloan Kettering Inst Immunol Program New York NY USA;

    Sloan Kettering Inst Dept Med Infect Dis Serv New York NY USA|Sloan Kettering Inst Immunol Program New York NY USA;

    Sloan Kettering Inst Dept Med Infect Dis Serv New York NY USA|Sloan Kettering Inst Immunol Program New York NY USA;

    Sloan Kettering Inst Dept Med Infect Dis Serv New York NY USA|Sloan Kettering Inst Immunol Program New York NY USA;

    Mem Sloan Kettering Canc Ctr Dept Lab Med 1275 York Ave New York NY 10021 USA;

    Mem Sloan Kettering Canc Ctr Dept Lab Med 1275 York Ave New York NY 10021 USA;

    Duke Univ Sch Med Div Hematol Malignancies & Cellular Therapy Durham NC USA;

    Duke Univ Sch Med Div Hematol Malignancies & Cellular Therapy Durham NC USA;

    Duke Univ Sch Med Div Hematol Malignancies & Cellular Therapy Durham NC USA;

    Duke Univ Sch Med Div Hematol Malignancies & Cellular Therapy Durham NC USA;

    Duke Univ Sch Med Div Hematol Malignancies & Cellular Therapy Durham NC USA;

    Sloan Kettering Inst Dept Med Infect Dis Serv New York NY USA|Sloan Kettering Inst Immunol Program New York NY USA;

    Mem Sloan Kettering Canc Ctr Dept Med Adult Bone Marrow Transplantat Serv 1275 York Ave New York NY 10021 USA|Weill Cornell Med Coll New York NY USA;

    Mem Sloan Kettering Canc Ctr Dept Med Adult Bone Marrow Transplantat Serv 1275 York Ave New York NY 10021 USA|Weill Cornell Med Coll New York NY USA;

    Mem Sloan Kettering Canc Ctr Sloan Kettering Inst Computat & Syst Biol Program 1275 York Ave New York NY 10021 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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