Immune-cell shutdown harms old brains

Neher Jonas J.

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Immune-cell shutdown harms old brains

机译：免疫细胞关闭损害旧大脑

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Immune cells called macrophages have been found to shut down major metabolic pathways during ageing. Restoring metabolism in these cells is sufficient to alleviate age-associated cognitive decline in mice.Cognition restored by inhibiting EP2 receptor proteins in macrophages.

机译：已发现称为巨噬细胞的免疫细胞在老化期间关闭了主要代谢途径。在这些细胞中恢复新陈代谢足以缓解小鼠的年龄相关的认知下降。通过抑制巨噬细胞中的EP2受体蛋白来恢复认知。

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来源
《Nature》 |2021年第7844期|44-45|共2页
作者
Neher Jonas J.;
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作者单位

German Ctr Neurodegenerat Dis D-72076 Tubingen Germany|Univ Tubingen Hertie Inst Clin Brain Res Dept Cellular Neurol Tubingen Germany;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
Ageing; Immunology; Metabolism;

机译：老化;免疫学;新陈代谢;

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Immune-cell shutdown harms old brains

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