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首页> 外文期刊>Nature >A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate
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A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

机译：单剂量活化衰减的YF17D - 矢量化SARS-COV-2疫苗候选人

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摘要

The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the development of safe, efficacious and fast-acting vaccines. Several vaccine platforms are being leveraged for a rapid emergency response~(1). Here we describe the development of a candidate vaccine (YF-S0) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that uses live-attenuated yellow fever 17D (YF17D) vaccine as a vector to express a noncleavable prefusion form of the SARS-CoV-2 spike antigen. We assess vaccine safety, immunogenicity and efficacy in several animal models. YF-S0 has an excellent safety profile and induces high levels of SARS-CoV-2 neutralizing antibodies in hamsters (Mesocricetus auratus), mice (Mus musculus) and cynomolgus macaques (Macaca fascicularis), and-concomitantly-protective immunity against yellow fever virus. Humoral immunity is complemented by a cellular immune response with favourable T helper 1 polarization, as profiled in mice. In a hamster model~(2)and in macaques, YF-S0 prevents infection with SARS-CoV-2. Moreover, a single dose conferred protection from lung disease in most of the vaccinated hamsters within as little as 10 days. Taken together, the quality of the immune responses triggered and the rapid kinetics by which protective immunity can be attained after a single dose warrant further development of this potent SARS-CoV-2 vaccine candidate.
机译：2019年冠状病毒疾病的扩大大部分（Covid-19）需要开发安全，有效和快速的疫苗。用于快速应急响应的几种疫苗平台〜（1）。在这里，我们描述了用于严重急性呼吸综合征冠状病毒2（SARS-COV-2）的候选疫苗（YF-S0）的开发，其使用活化的黄热病17D（YF17D）疫苗作为载体以表达不可分析的预防形式SARS-COV-2穗抗原。我们评估几种动物模型中的疫苗安全性，免疫原性和疗效。 YF-S0具有出色的安全性，并诱导仓鼠（Mesocricetus auratus），小鼠（Mus Musculus）和Cynomolgus macaques（猕猴属植物），以及伴随着黄热病病毒的保护性免疫力的高水平的SARS-COV-2中和抗体。 。具有良好的T辅助1偏振的细胞免疫应答的体液免疫，如小鼠的型成型。在仓鼠模型〜（2）和Macaques中，YF-S0可防止SARS-COV-2感染。此外，单剂量在大部分疫苗的仓鼠中达到肺病的保护。一起携带的免疫反应质量和触发保护性免疫的快速动力学，可以在单一剂量担保后获得这种有效的SARS-COV-2疫苗候选者的进一步发展。

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  • 来源
    《Nature》 |2021年第7845期|320-325|共6页
  • 作者

    Lorena Sanchez-Felipe; Thomas Vercruysse; Sapna Sharma; Ji Ma; Viktor Lemmens; Dominique Van Looveren; Mahadesh Prasad Arkalagud Javarappa; Robbert Boudewijns; Bert Malengier-Devlies; Laurens Liesenborghs; Suzanne J F Kaptein; Carolien De Keyzer; Lindsey Bervoets; Sarah Debaveye; Madina Rasulova; Laura Seldeslachts; Li-Hsin Li; Sander Jansen; Michael Bright Yakass; Babs E Verstrepen; Kinga P Böszörményi; Gwendoline Kiemenyi-Kayere; Nikki van Driel; Osbourne Quaye; Xin Zhang; Sebastiaan Ter Horst; Niraj Mishra; Ward Deboutte; Jelle Matthijnssens; Lotte Coelmont; Corinne Vandermeulen; Elisabeth Heylen; Valentijn Vergote; Dominique Schols; Zhongde Wang; Willy Bogers; Thijs Kuiken; Ernst Verschoor; Christopher Cawthorne; Koen Van Laere; Ghislain Opdenakker; Greetje Vande Velde; Birgit Weynand; Dirk E Teuwen; Patrick Matthys; Johan Neyts; Hendrik Jan Thibaut; Kai Dallmeier;

  • 作者单位

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Translational Platform Virology and Chemotherapy (TPVC) KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Translational Platform Virology and Chemotherapy (TPVC) KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Immunity and Inflammation Research Group Immunobiology Unit KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Translational Platform Virology and Chemotherapy (TPVC) KU Leuven;

    KU Leuven Department of Imaging and Pathology Biomedical MRI and MoSAIC KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN)|West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) Department of Biochemistry Cell and Molecular Biology University of Ghana;

    Department of Virology Biomedical Primate Research Centre (BPRC);

    Department of Virology Biomedical Primate Research Centre (BPRC);

    Department of Virology Biomedical Primate Research Centre (BPRC);

    Animal Science Department Biomedical Primate Research Centre (BPRC);

    Global Virus Network (GVN)|West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) Department of Biochemistry Cell and Molecular Biology University of Ghana;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN)|Gene Therapy Division Intas Pharmaceuticals;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Laboratorium Klinische en Epidemiologische Virologie KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Laboratorium Klinische en Epidemiologische Virologie KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    Leuven University Vaccinology Center (LUVAC) KU Leuven|KU Leuven Department of Public Health and Primary Care KU Keuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven;

    Department of Animal Dairy and Veterinary Sciences Utah State University;

    Department of Virology Biomedical Primate Research Centre (BPRC);

    Department of Viroscience Erasmus University Medical Center;

    Department of Virology Biomedical Primate Research Centre (BPRC);

    KU Leuven Department of Imaging and Pathology Nuclear Medicine and Molecular Imaging KU Leuven;

    KU Leuven Department of Imaging and Pathology Nuclear Medicine and Molecular Imaging KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Immunity and Inflammation Research Group Immunobiology Unit KU Leuven;

    KU Leuven Department of Imaging and Pathology Biomedical MRI and MoSAIC KU Leuven;

    KU Leuven Department of Imaging and Pathology Translational Cell and Tissue Research KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Immunity and Inflammation Research Group Immunobiology Unit KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Translational Platform Virology and Chemotherapy (TPVC) KU Leuven;

    KU Leuven Department of Microbiology Immunology and Transplantation Rega Institute Virology and Chemotherapy Molecular Vaccinology and Vaccine Discovery KU Leuven|Global Virus Network (GVN);

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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