• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >C. difficile exploits a host metabolite produced during toxin-mediated disease
【24h】

C. difficile exploits a host metabolite produced during toxin-mediated disease

机译：C.艰难梭菌利用在毒素介导的疾病中产生的宿主代谢物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Several enteric pathogens can gain specific metabolic advantages over other members of the microbiota by inducing host pathology and inflammation. The pathogen Clostridium difficile is responsible for a toxin-mediated colitis that causes 450,000 infections and 15,000 deaths in the United States each year~(1); however, the molecular mechanisms by which C. difficile benefits from this pathology remain unclear. To understand how the metabolism of C. difficile adapts to the inflammatory conditions that its toxins induce, here we use RNA sequencing to define, in a mouse model, the metabolic states of wild-type C. difficile and of an isogenic mutant that lacks toxins. By combining bacterial and mouse genetics, we demonstrate that C. difficile uses sorbitol derived from both diet and host. Host-derived sorbitol is produced by the enzyme aldose reductase, which is expressed by diverse immune cells and is upregulated during inflammation-including during toxin-mediated disease induced by C. difficile. This work highlights a mechanism by which C. difficile can use a host-derived nutrient that is generated during toxin-induced disease by an enzyme that has not previously been associated with infection.
机译：通过诱导宿主病理学和炎症，几种肠道病原体可以通过微生物群的其他成员获得特定的代谢优势。病原体梭菌差异是毒素介导的结肠炎，每年导致美国的450,000个感染和15,000人死亡〜（1）;然而，来自这种病理学的C.艰难效益的分子机制仍然不清楚。要了解C.艰难梭菌的代谢如何适应其毒素诱导的炎性条件，这里我们使用RNA测序在小鼠模型中定义野生型C.艰难梭菌和缺乏毒素的中生突变体的代谢状态。通过组合细菌和小鼠遗传学，我们证明C.艰难术用衍生自饮食和宿主的山梨糖醇。宿主衍生的山梨糖醇由酶醛糖还原酶产生，该醛糖还原酶由不同的免疫细胞表达，并且在炎症期间上调 - 包括C.偶联诱导的毒素介导的疾病。这项工作突出了一种机制，C.艰难梭菌可以使用毒素诱导的疾病在毒素诱导的疾病中产生的宿主衍生的营养素，该酶未与感染未经感染。

著录项

  • 来源
    《Nature》 |2021年第7858期|261-265|共5页
  • 作者

    Kali M Pruss; Justin L Sonnenburg;

  • 作者单位

    Department of Microbiology and Immunology Stanford University School of Medicine;

    Department of Microbiology and Immunology Stanford University School of Medicine;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号