• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >A body map of somatic mutagenesis in morphologically normal human tissues
【24h】

A body map of somatic mutagenesis in morphologically normal human tissues

机译：形态学正常的人体组织体细胞诱变的身体图

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Somatic mutations that accumulate in normal tissues are associated with ageing and disease~(1,2). Here we performed a comprehensive genomic analysis of 1,737 morphologically normal tissue biopsies of 9 organs from 5 donors. We found that somatic mutation accumulations and clonal expansions were widespread, although to variable extents, in morphologically normal human tissues. Somatic copy number alterations were rarely detected, except for in tissues from the oesophagus and cardia. Endogenous mutational processes with the SBS1 and SBS5 mutational signatures are ubiquitous among normal tissues, although they exhibit different relative activities. Exogenous mutational processes operate in multiple tissues from the same donor. We reconstructed the spatial somatic clonal architecture with sub-millimetre resolution. In the oesophagus and cardia, macroscopic somatic clones that expanded to hundreds of micrometres were frequently seen, whereas in tissues such as the colon, rectum and duodenum, somatic clones were microscopic in size and evolved independently, possibly restricted by local tissue microstructures. Our study depicts a body map of somatic mutations and clonal expansions from the same individual.
机译：在正常组织中积聚的体细胞突变与老化和疾病有关〜（1,2）。在这里，我们对来自5个供体的9个器官的综合基因组分析进行了1,737个形态正常组织活组织检查。我们发现，体细胞突变累积和克隆膨胀虽然普遍存在，但在形态学上正常的人体组织中可变延伸率。在食道和贲门中的组织中，很少检测体细胞拷贝数改变。具有SBS1和SBS5突变签名的内源性突变过程在正常组织中普遍存在，尽管它们表现出不同的相对活性。外源性突变过程在来自同一供体的多个组织中操作。我们重建了具有亚毫米分辨率的空间躯体克隆架构。在食道和Cardia中，经常看到扩展到数百微量测量的宏观体细胞克隆，而在结肠，直肠和十二指肠的组织中，体细胞克隆的尺寸是微观的，并且独立地演变，可能受到局部组织微观结构的限制。我们的研究描绘了来自同一个人的体细胞突变和克隆膨胀的身体图。

著录项

  • 来源
    《Nature》 |2021年第7876期|398-403|共6页
  • 作者

    Ruoyan Li; Lin Di; Jie Li; Wenyi Fan; Yachen Liu; Wenjia Guo; Weiling Liu; Lu Liu; Qiong Li; Liping Chen; Yamei Chen; Chuanwang Miao; Hongjin Liu; Yuqian Wang; Yuling Ma; Deshu Xu; Dongxin Lin; Yanyi Huang; Jianbin Wang; Fan Bai; Chen Wu;

  • 作者单位

    Biomedical Pioneering Innovation Center (BIOPIC) School of Life Sciences Peking University (PKU)|Beijing Advanced Innovation Center for Genomics (ICG) Peking University;

    Biomedical Pioneering Innovation Center (BIOPIC) School of Life Sciences Peking University (PKU)|Beijing Advanced Innovation Center for Genomics (ICG) Peking University;

    School of Life Sciences Tsinghua-Peking Center for Life Sciences Tsinghua University|Beijing Advanced Innovation Center for Structural Biology (ICSB) Tsinghua University;

    Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC);

    Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC);

    Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC);

    Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC);

    Biomedical Pioneering Innovation Center (BIOPIC) School of Life Sciences Peking University (PKU)|Beijing Advanced Innovation Center for Genomics (ICG) Peking University;

    School of Life Sciences Tsinghua-Peking Center for Life Sciences Tsinghua University|Beijing Advanced Innovation Center for Structural Biology (ICSB) Tsinghua University;

    Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC);

    Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC);

    Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC);

    Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC);

    Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC);

    Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC);

    Biomedical Pioneering Innovation Center (BIOPIC) School of Life Sciences Peking University (PKU)|Beijing Advanced Innovation Center for Genomics (ICG) Peking University;

    Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)|Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University|Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China|CAMS Key Laboratory of Cancer Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical College;

    Biomedical Pioneering Innovation Center (BIOPIC) School of Life Sciences Peking University (PKU)|Beijing Advanced Innovation Center for Genomics (ICG) Peking University|College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular Sciences Peking University|Peking-Tsinghua Center for Life Sciences Peking University|Institute for Cell Analysis Shenzhen Bay Laboratory;

    School of Life Sciences Tsinghua-Peking Center for Life Sciences Tsinghua University|Beijing Advanced Innovation Center for Structural Biology (ICSB) Tsinghua University;

    Biomedical Pioneering Innovation Center (BIOPIC) School of Life Sciences Peking University (PKU)|Beijing Advanced Innovation Center for Genomics (ICG) Peking University|Center for Translational Cancer Research Peking University First Hospital;

    Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)|Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University|CAMS Key Laboratory of Cancer Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical College|CAMS Oxford Institute (COI) CAMS;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号