Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

Delannoy-Bruno Omar; Desai Chandani; Raman Arjun S.; Chen Robert Y.; Hibberd Matthew C.; Cheng Jiye; Han Nathan; Castillo Juan J.; Couture Garret; Lebrilla Carlito B.; Barve Ruteja A.; Lombard Vincent; Henrissat Bernard; Leyn Semen A.; Rodionov Dmitry A.; Osterman Andrei L.; Hayashi David K.; Meynier Alexandra; Vinoy Sophie; Kirbach Kyleigh; Wilmot Tara; Heath Andrew C.; Klein Samuel; Barratt Michael J.; Gordon Jeffrey I

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Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

机译：评估侏毒小鼠和人类的微生物组导向的纤维零食

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Changing food preferences brought about by westernization that have deleterious health effects(1,2)-combined with myriad forces that are contributing to increased food insecurity-are catalysing efforts to identify more nutritious and affordable foods(3). Consumption of dietary fibre can help to prevent cardiovascular disease, type 2 diabetes and obesity(4-6). A substantial number of reports have explored the effects of dietary fibre on the gut microbial community(7-9). However, the microbiome is complex, dynamic and exhibits considerable intra- and interpersonal variation in its composition and functions. The large number of potential interactions between the components of the microbiome makes it challenging to define the mechanisms by which food ingredients affect community properties. Here we address the question of how foods containing different fibre preparations can be designed to alter functions associated with specific components of the microbiome. Because a marked increase in snack consumption is associated with westernization, we formulated snack prototypes using plant fibres from different sustainable sources that targeted distinct features of the gut microbiomes of individuals with obesity when transplanted into gnotobiotic mice. We used these snacks to supplement controlled diets that were consumed by adult individuals with obesity or who were overweight. Fibre-specific changes in their microbiomes were linked to changes in their plasma proteomes indicative of an altered physiological state.

机译：改变食物偏好是通过西方化引起有害健康影响（1,2） - 与无数的武器组成，这些力量导致粮食不安全的增加 - 是刺激更加营养丰富的食物（3）。膳食纤维的消耗可以有助于预防心血管疾病，2型糖尿病和肥胖（4-6）。大量报告探讨了膳食纤维对肠道微生物群落（7-9）的影响。然而，微生物组是复杂的，动态的，并且在其组成和功能中表现出相当大的内际变化。微生物组的组分之间的大量潜在相互作用使得定义食品成分影响社区性质的机制挑战。在这里，我们解决了如何设计含有不同纤维制剂的食物的问题，以改变与微生物组的特定组分相关的功能。由于零食消耗的显着增加与西方化有关，我们使用来自不同可持续源的植物纤维制定了植物纤维，该植物纤维在移植到胎虫小鼠中时患有肥胖的肠道微生物的肠道微生物的不同特征。我们使用这些零食来补充受肥胖或超重的成年人消耗的控制饮食。它们的微生物体的纤维特异性变化与其血浆蛋白质蛋白质蛋白质蛋白质的变化有关，这表明生理状态改变。

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《Nature》 |2021年第7865期|91-95|共5页
作者
Delannoy-Bruno Omar; Desai Chandani; Raman Arjun S.; Chen Robert Y.; Hibberd Matthew C.; Cheng Jiye; Han Nathan; Castillo Juan J.; Couture Garret; Lebrilla Carlito B.; Barve Ruteja A.; Lombard Vincent; Henrissat Bernard; Leyn Semen A.; Rodionov Dmitry A.; Osterman Andrei L.; Hayashi David K.; Meynier Alexandra; Vinoy Sophie; Kirbach Kyleigh; Wilmot Tara; Heath Andrew C.; Klein Samuel; Barratt Michael J.; Gordon Jeffrey I;
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作者单位

Washington Univ Sch Med Edison Family Ctr Genome Sci & Syst Biol St Louis MO 63110 USA|Washington Univ Sch Med Ctr Gut Microbiome & Nutr Res St Louis MO 63110 USA;

Washington Univ Sch Med Edison Family Ctr Genome Sci & Syst Biol St Louis MO 63110 USA|Washington Univ Sch Med Ctr Gut Microbiome & Nutr Res St Louis MO 63110 USA;

Washington Univ Sch Med Edison Family Ctr Genome Sci & Syst Biol St Louis MO 63110 USA|Washington Univ Sch Med Ctr Gut Microbiome & Nutr Res St Louis MO 63110 USA|Washington Univ Sch Med Dept Pathol & Immunol St Louis MO 63110 USA;

Washington Univ Sch Med Edison Family Ctr Genome Sci & Syst Biol St Louis MO 63110 USA|Washington Univ Sch Med Ctr Gut Microbiome & Nutr Res St Louis MO 63110 USA;

Washington Univ Sch Med Edison Family Ctr Genome Sci & Syst Biol St Louis MO 63110 USA|Washington Univ Sch Med Ctr Gut Microbiome & Nutr Res St Louis MO 63110 USA|Washington Univ Sch Med Dept Pathol & Immunol St Louis MO 63110 USA;

Washington Univ Sch Med Edison Family Ctr Genome Sci & Syst Biol St Louis MO 63110 USA|Washington Univ Sch Med Ctr Gut Microbiome & Nutr Res St Louis MO 63110 USA|Washington Univ Sch Med Dept Pathol & Immunol St Louis MO 63110 USA;

Washington Univ Sch Med Edison Family Ctr Genome Sci & Syst Biol St Louis MO 63110 USA|Washington Univ Sch Med Ctr Gut Microbiome & Nutr Res St Louis MO 63110 USA;

Univ Calif Davis Dept Chem Davis CA 95616 USA;

Univ Calif Davis Dept Chem Davis CA 95616 USA;

Univ Calif Davis Dept Chem Davis CA 95616 USA;

Washington Univ Sch Med Dept Genet St Louis MO 63110 USA;

Ctr Natl Rech Sci Architecture & Fonct Macromol Biol Marseille France|Aix Marseille Univ Marseille France;

Ctr Natl Rech Sci Architecture & Fonct Macromol Biol Marseille France|Aix Marseille Univ Marseille France|King Abdulaziz Univ Dept Biol Sci Jeddah Saudi Arabia;

Sanford Burnham Prebys Med Discovery Inst Infect & Inflammatory Dis Ctr La Jolla CA USA;

Sanford Burnham Prebys Med Discovery Inst Infect & Inflammatory Dis Ctr La Jolla CA USA|Russian Acad Sci AA Kharkevich Inst Informat Transmiss Problems Moscow Russia;

Sanford Burnham Prebys Med Discovery Inst Infect & Inflammatory Dis Ctr La Jolla CA USA;

Mondelez GLobal LLC Chicago IL USA;

Mondelez GLobal LLC Chicago IL USA;

Mondelez GLobal LLC Chicago IL USA;

Washington Univ Sch Med Dept Med St Louis MO 63110 USA;

Washington Univ Sch Med Dept Med St Louis MO 63110 USA;

Washington Univ Sch Med Dept Psychiat St Louis MO 63110 USA;

Washington Univ Sch Med Dept Med St Louis MO 63110 USA;

Washington Univ Sch Med Edison Family Ctr Genome Sci & Syst Biol St Louis MO 63110 USA|Washington Univ Sch Med Ctr Gut Microbiome & Nutr Res St Louis MO 63110 USA|Washington Univ Sch Med Dept Pathol & Immunol St Louis MO 63110 USA;

Washington Univ Sch Med Edison Family Ctr Genome Sci & Syst Biol St Louis MO 63110 USA|Washington Univ Sch Med Ctr Gut Microbiome & Nutr Res St Louis MO 63110 USA|Washington Univ Sch Med Dept Pathol & Immunol St Louis MO 63110 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Sequence variant analysis reveals poor correlations in microbial taxonomic abundance between humans and mice after gnotobiotic transfer [J] . Fouladi Farnaz, Glenny Elaine M., Bulik-Sullivan Emily C., The ISME journal emultidisciplinary journal of microbial ecology . 2020,第7期

机译：序列变体分析揭示了脑梗转移后人和小鼠之间的微生物分类分类差异不良
2. A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice [J] . Marcobal A., Kashyap P.C., Nelson T.A., The ISME journal emultidisciplinary journal of microbial ecology . 2013,第10期

机译：关于人肠道菌群如何影响人源化和致癌小鼠的代谢组学的代谢组学观点
3. Effect of Bovine or Human Milk on the Establishment of Bifidobacterium bifidum and Some Other Bacteria from the Human Neonatal Microflora in Gnotobiotic Mice [J] . S. Hudault, C. Bridonneau, R. Ducluzeau, Microbial Ecology in Health and Disease . 1991,第1期

机译：牛乳或人乳对人双歧杆菌双歧杆菌及其他一些细菌从人源微生物菌群中建立的影响
4. Shotgun Proteomic Analysis of a Shotgun Proteomic Analysis of a Model 7-Member Human Gut Microbiota created in Gnotobiotic Mice [C] . A. Russell, N. C. VerBerkmoes, N. McNulty, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：鼠枪蛋白质组学分析术语术语7-成员人体肠道微生物的霰弹枪蛋白质组学分析
5. Bacterial Targets of Gut Mucosal Immunoglobulin A Responses in Healthy and Undernourished Children, and in Gnotobiotic Mice Colonized with Human Gut Microbiota. [D] . Planer, Joseph. 2017

机译：在健康和营养不良的儿童以及定植于人类肠道微生物群的致敏小鼠中肠道粘膜免疫球蛋白A的细菌目标。
6. Sequence variant analysis reveals poor correlations in microbial taxonomic abundance between humans and mice after gnotobiotic transfer [O] . Farnaz Fouladi, Elaine M. Glenny, Emily C. Bulik-Sullivan, 2020

机译：序列变体分析揭示了脑梗转移后人和小鼠之间的微生物分类学丰富的相关性差
7. The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice [O] . P. J. Turnbaugh, V. K. Ridaura, J. J. Faith, 2009

机译：饮食对人体肠道微生物组的影响：人源性骨髓小鼠的偏见分析

Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

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