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The mouse cortico basal ganglia-thalamic network

机译：小鼠Cortico Basal Ganglia-Thalamic网络

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摘要

The cortico-basal ganglia-thalamo-cortical loop is one of the fundamental network motifs in the brain. Revealing its structural and functional organization is critical to understanding cognition, sensorimotor behaviour, and the natural history of many neurological and neuropsychiatric disorders. Classically, this network is conceptualized to contain three information channels: motor, limbic and associative~(1-4). Yet this three-channel view cannot explain the myriad functions of the basal ganglia. We previously subdivided the dorsal striatum into 29 functional domains on the basis of the topography of inputs from the entire cortex~(5). Here we map the multi-synaptic output pathways of these striatal domains through the globus pallidus external part (GPe), substantia nigra reticular part (SNr), thalamic nuclei and cortex. Accordingly, we identify 14 SNr and 36 GPe domains and a direct cortico-SNr projection. The striatonigral direct pathway displays a greater convergence of striatal inputs than the more parallel striatopallidal indirect pathway, although direct and indirect pathways originating from the same striatal domain ultimately converge onto the same postsynaptic SNr neurons. Following the SNr outputs, we delineate six domains in the parafascicular and ventromedial thalamic nuclei. Subsequently, we identify six parallel cortico-basal ganglia-thalamic subnetworks that sequentially transduce specific subsets of cortical information through every elemental node of the cortico-basal ganglia-thalamic loop. Thalamic domains relay this output back to the originating corticostriatal neurons of each subnetwork in a bona fide closed loop.
机译：Cortico-basal Ganglia-thalamo-皮质环是大脑中的基本网络图案之一。揭示其结构和功能组织对于了解认知，感觉运动，以及许多神经学和神经精神疾病的自然历史至关重要。经典上，该网络概念化为包含三个信息渠道：电机，肢体和关联〜（1-4）。然而，这个三声道视图无法解释基础神经节的无数函数。我们之前将背体细分为29个功能域，基于整个皮质〜（5）的输入的地形。在这里，我们通过Globus pallidus外部部分（GPE），Implica NIGRA网状部分（SNR），丘脑核和皮质来映射这些纹状体域的多突触输出途径。因此，我们鉴定了14个SNR和36个GPE结构域和直接的Cortico-SNR投影。 STIATONIGRAL直接途径显示比更平行的纹状体间接途径更大的纹状体输入的收敛性，尽管源自相同的尖端结构域的直接和间接途径最终会聚到同一突触后的SNR神经元。在SNR输出之后，我们将六个域划分在Paraidascular和口腔内丘脑核中。随后，我们识别六个并行皮质基底神经节 - 塔拉姆分段，通过Cortico-Banal Ganglia-Thalamic环路的每个元素节点顺序地转换皮质信息的特定子集。丘脑域将此输出继电器回到BONA FIDE闭环中的每个子网的始发皮质静脉神经元。

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  • 来源
    《Nature》 |2021年第7879期|188-194|共7页
  • 作者

    Nicholas N Foster; Joshua Barry; Laura Korobkova; Luis Garcia; Lei Gao; Marlene Becerra; Yasmine Sherafat; Bo Peng; Xiangning Li; Jun-Hyeok Choi; Lin Gou; Brian Zingg; Sana Azam; Darrick Lo; Neda Khanjani; Bin Zhang; Jim Stanis; Ian Bowman; Kaelan Cotter; Chunru Cao; Seita Yamashita; Amanda Tugangui; Anan Li; Tao Jiang; Xueyan Jia; Zhao Feng; Sarvia Aquino; Hyun-Seung Mun; Muye Zhu; Anthony Santarelli; Nora L Benavidez; Monica Song; Gordon Dan; Marina Fayzullina; Sarah Ustrell; Tyler Boesen; David L Johnson; Hanpeng Xu; Michael S Bienkowski; X William Yang; Hui Gong; Michael S Levine; Ian Wickersham; Qingming Luo; Joel D Hahn; Byung Kook Lim; Li I Zhang; Carlos Cepeda; Houri Hintiryan; Hong-Wei Dong;

  • 作者单位

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Jane and Terry Semel Institute for Neuroscience and Human Behavior Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine at UCLA;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Zilkha Neurogenetic Institute Keck School of Medicine University of Southern California;

    Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics MoE Key Laboratory for Biomedical Photonics School of Engineering Sciences Huazhong University of Science and Technology|HUST-Suzhou Institute for Brainsmatics JITRI Institute for Brainsmatics;

    Neurobiology Section Division of Biological Sciences University of California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics MoE Key Laboratory for Biomedical Photonics School of Engineering Sciences Huazhong University of Science and Technology|HUST-Suzhou Institute for Brainsmatics JITRI Institute for Brainsmatics|CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Science;

    HUST-Suzhou Institute for Brainsmatics JITRI Institute for Brainsmatics;

    HUST-Suzhou Institute for Brainsmatics JITRI Institute for Brainsmatics;

    HUST-Suzhou Institute for Brainsmatics JITRI Institute for Brainsmatics;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    Jane and Terry Semel Institute for Neuroscience and Human Behavior Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine at UCLA|Center for Neurobehavioral Genetics Jane and Terry Semel Institute for Neuroscience;

    Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics MoE Key Laboratory for Biomedical Photonics School of Engineering Sciences Huazhong University of Science and Technology|HUST-Suzhou Institute for Brainsmatics JITRI Institute for Brainsmatics|CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Science;

    Jane and Terry Semel Institute for Neuroscience and Human Behavior Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine at UCLA;

    McGovern Institute for Brain Research Massachusetts Institute of Technology;

    Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics MoE Key Laboratory for Biomedical Photonics School of Engineering Sciences Huazhong University of Science and Technology|HUST-Suzhou Institute for Brainsmatics JITRI Institute for Brainsmatics|School of Biomedical Engineering Hainan University;

    Department of Biological Sciences University of Southern California;

    Neurobiology Section Division of Biological Sciences University of California;

    Zilkha Neurogenetic Institute Keck School of Medicine University of Southern California;

    Jane and Terry Semel Institute for Neuroscience and Human Behavior Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine at UCLA;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine at UCLA|Mark and Mary Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California;

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