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Dopamine facilitates associative memory encoding in the entorhinal cortex

机译：多巴胺促进了Entorlinal Cortex中的关联内存编码

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摘要

Mounting evidence shows that dopamine in the striatum is critically involved in reward-based reinforcement learning(1,2). However, it remains unclear how dopamine reward signals influence the entorhinal-hippocampal circuit, another brain network that is crucial for learning and memory(3-5). Here, using cell-type-specific electrophysiological recording(6), we show that dopamine signals from the ventral tegmental area and substantia nigra control the encoding of cue-reward association rules in layer 2a fan cells of the lateral entorhinal cortex (LEC). When mice learned novel olfactory cue-reward associations using a pre-learned association rule, spike representations of LEC fan cells grouped newly learned rewarded cues with a pre-learned rewarded cue, but separated them from a pre-learned unrewarded cue. Optogenetic inhibition of fan cells impaired the learning of new associations while sparing the retrieval of pre-learned memory. Using fibre photometry, we found that dopamine sends novelty-induced reward expectation signals to the LEC. Inhibition of LEC dopamine signals disrupted the associative encoding of fan cells and impaired learning performance. These results suggest that LEC fan cells represent a cognitive map of abstract task rules, and that LEC dopamine facilitates the incorporation of new memories into this map.
机译：安装证据表明，纹状体中的多巴胺是批判性地参与基于奖励的强化学习（1,2）。然而，它仍然不明确多巴胺奖励信号如何影响Entorlinal-HippoDPALL电路，这是一个对学习和记忆至关重要的脑网络（3-5）。这里，使用细胞类型特异性电生理学记录（6），我们表明来自腹侧三谷物区域和Implia NIGRA的多巴胺信号控制了横向梭形皮质（LEC）层2A风扇细胞中的CUE奖励关联规则的编码。当小鼠使用预先学习的关联规则学习了新型嗅觉CUE奖励协会时，LEC粉底的尖峰表示与预先学习的奖励提示进行了新学习的奖励线索，但将他们与预先学习的未奖励的提示分开。扇形抑制风扇细胞的抑制损害了新关联的学习，同时保留了预先学习记忆的检索。使用纤维测光测定，我们发现多巴胺向LEC发送新奇诱导的奖励期望信号。 LEC多巴胺信号的抑制中断了风扇细胞的关联编码和学习性能受损。这些结果表明，LEC风扇电池代表抽象任务规则的认知地图，并且LEC多巴胺促进了将新记忆纳入了该地图。

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  • 来源
    《Nature》 |2021年第7880期|321-326|共6页
  • 作者

    Lee Jason Y.; Jun Heechul; Soma Shogo; Nakazono Tomoaki; Shiraiwa Kaori; Dasgupta Ananya; Nakagawa Tatsuki; Xie Jiayun L.; Chavez Jasmine; Romo Rodrigo; Yungblut Sandra; Hagihara Meiko; Murata Koshi; Igarashi Kei M.;

  • 作者单位

    Univ Calif Irvine Dept Anat & Neurobiol Sch Med Irvine CA 92717 USA;

    Univ Calif Irvine Dept Anat & Neurobiol Sch Med Irvine CA 92717 USA;

    Univ Calif Irvine Dept Anat & Neurobiol Sch Med Irvine CA 92717 USA|Kyoto Prefectural Univ Med Dept Mol Cell Physiol Kyoto Japan;

    Univ Calif Irvine Dept Anat & Neurobiol Sch Med Irvine CA 92717 USA|Fukushima Med Univ Dept Syst Neurosci Fukushima Japan;

    Univ Calif Irvine Dept Anat & Neurobiol Sch Med Irvine CA 92717 USA;

    Univ Calif Irvine Dept Anat & Neurobiol Sch Med Irvine CA 92717 USA;

    Univ Calif Irvine Dept Anat & Neurobiol Sch Med Irvine CA 92717 USA;

    Univ Calif Irvine Dept Anat & Neurobiol Sch Med Irvine CA 92717 USA;

    Univ Calif Irvine Dept Anat & Neurobiol Sch Med Irvine CA 92717 USA;

    Univ Calif Irvine Dept Anat & Neurobiol Sch Med Irvine CA 92717 USA;

    Univ Calif Irvine Dept Anat & Neurobiol Sch Med Irvine CA 92717 USA;

    Univ Fukui Div Brain Struct & Funct Fac Med Sci Fukui Japan;

    Univ Fukui Div Brain Struct & Funct Fac Med Sci Fukui Japan;

    Univ Calif Irvine Dept Anat & Neurobiol Sch Med Irvine CA 92717 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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