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Neural control of affiliative touch in prosocial interaction

机译：神经互动隶属关系的神经控制

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摘要

The ability to help and care for others fosters social cohesiveness and is vital to the physical and emotional well-being of social species, including humans(1-3). Affiliative social touch, such as allogrooming (grooming behaviour directed towards another individual), is a major type of prosocial behaviour that provides comfort to others(1-6). Affiliative touch serves to establish and strengthen social bonds between animals and can help to console distressed conspecifics. However, the neural circuits that promote prosocial affiliative touch have remained unclear. Here we show that mice exhibit affiliative allogrooming behaviour towards distressed partners, providing a consoling effect. The increase in allogrooming occurs in response to different types of stressors and can be elicited by olfactory cues from distressed individuals. Using microendoscopic calcium imaging, we find that neural activity in the medial amygdala (MeA) responds differentially to naive and distressed conspecifics and encodes allogrooming behaviour. Through intersectional functional manipulations, we establish a direct causal role of the MeA in controlling affiliative allogrooming and identify a select, tachykinin-expressing subpopulation of MeA GABAergic (gamma-aminobutyric-acid-expressing) neurons that promote this behaviour through their projections to the medial preoptic area. Together, our study demonstrates that mice display prosocial comforting behaviour and reveals a neural circuit mechanism that underlies the encoding and control of affiliative touch during prosocial interactions.
机译：帮助和关心其他人的能力，促进社会凝聚力，对社会物种的身体和情感福祉至关重要，包括人类（1-3）。隶属性社会触感（如异种草）是对另一个人的梳理行为，是对他人（1-6）提供舒适性的主要样本行为。隶属触摸致力于在动物之间建立和加强社会债券，可以帮助控制陷入困境的群体。然而，促进女性归属触摸的神经电路仍然不清楚。在这里，我们表明，小鼠对痛苦的合作伙伴展示了隶属性的异教徒行为，提供了慰问的效果。响应于不同类型的压力源而发生异化的增加，并且可以由来自困难人员的嗅觉提示引发。使用微观透视钙成像，我们发现内侧杏仁达拉（MEA）中的神经活动差异地差异地与幼稚和苦恼的陷入困境，并编码了异种行为。通过交叉功能操纵，我们建立了MEA在控制隶属性异种的直接因果作用，并鉴定SELEC，Tachykinin表达MEA GABAIC（γ-氨基丁酸表达）神经元的亚群，通过它们的突起向内侧促进这种行为偏见区域。我们的研究在一起表明，小鼠展示了口语舒适行为，并揭示了神经电路机制，在女性相互作用期间归结了隶属关系的编码和控制。

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  • 来源
    《Nature》 |2021年第7884期|262-267|共6页
  • 作者

    Wu Ye Emily; Dang James; Kingsbury Lyle; Zhang Mingmin; Sun Fangmiao; Hu Rongfeng K.; Hong Weizhe;

  • 作者单位

    Univ Calif Los Angeles David Geffen Sch Med Dept Biol Chem Los Angeles CA 90095 USA|Univ Calif Los Angeles David Geffen Sch Med Dept Neurobiol Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Dept Biol Chem Los Angeles CA 90095 USA|Univ Calif Los Angeles David Geffen Sch Med Dept Neurobiol Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Dept Biol Chem Los Angeles CA 90095 USA|Univ Calif Los Angeles David Geffen Sch Med Dept Neurobiol Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Dept Biol Chem Los Angeles CA 90095 USA|Univ Calif Los Angeles David Geffen Sch Med Dept Neurobiol Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Dept Biol Chem Los Angeles CA 90095 USA|Univ Calif Los Angeles David Geffen Sch Med Dept Neurobiol Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Dept Biol Chem Los Angeles CA 90095 USA|Univ Calif Los Angeles David Geffen Sch Med Dept Neurobiol Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Dept Biol Chem Los Angeles CA 90095 USA|Univ Calif Los Angeles David Geffen Sch Med Dept Neurobiol Los Angeles CA 90095 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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