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Cellular anatomy of the mouse primary motor cortex

机译：小鼠初级电机皮层的细胞解剖

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摘要

An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted~(1). Here, as part of the collaborative Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul). Using genetic and viral labelling, barcoded anatomy resolved by sequencing, single-neuron reconstruction, whole-brain imaging and cloud-based neuroinformatics tools, we delineated the MOp-ul in 3D and refined its sublaminar organization. We defined around two dozen projection neuron types in the MOp-ul and derived an input-output wiring diagram, which will facilitate future analyses of motor control circuitry across molecular, cellular and system levels. This work provides a roadmap towards a comprehensive cellular-resolution description of mammalian brain architecture.
机译：理解大脑函数的重要步骤是建立具有蜂窝分辨率的结构框架，该细胞分辨率在哪些多级数据集可以集成和解释〜（1）。这里，作为协同脑倡议细胞人口普查网络（BICCN）的一部分，我们推导出一种基于细胞类型的基于细胞类型的解剖学描述，其一个示例性脑结构，小鼠初级电机皮层，上肢区域（MOP-UL）。使用遗传和病毒标记，通过测序，单神经元重建，全脑成像和基于云的神经素信息工具来解决的条形码解剖学，我们描绘了3D中的拖把-UL并改善了其子宫内组织。我们在MOP-UL中定义了大约二十二个投影神经元类型，并导出了输入输出接线图，这将促进对微量分子，细胞和系统水平的电机控制电路的未来分析。这项工作为哺乳动物脑建筑的全面细胞分辨说明提供了路线图。

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  • 来源
    《Nature》 |2021年第7879期|159-166|共8页
  • 作者

    Rodrigo Muñoz-Castañeda; Brian Zingg; Katherine S Matho; Xiaoyin Chen; Quanxin Wang; Nicholas N Foster; Anan Li; Arun Narasimhan; Karla E Hirokawa; Bingxing Huo; Samik Bannerjee; Laura Korobkova; Chris Sin Park; Young-Gyun Park; Michael S Bienkowski; Uree Chon; Diek W Wheeler; Xiangning Li; Yun Wang; Maitham Naeemi; Peng Xie; Lijuan Liu; Kathleen Kelly; Xu An; Sarojini M Attili; Ian Bowman; Anastasiia Bludova; Ali Cetin; Liya Ding; Rhonda Drewes; Florence DOrazi; Corey Elowsky; Stephan Fischer; William Galbavy; Lei Gao; Jesse Gillis; Peter A Groblewski; Lin Gou; Joel D Hahn; Joshua T Hatfield; Houri Hintiryan; Junxiang Jason Huang; Hideki Kondo; Xiuli Kuang; Philip Lesnar; Xu Li; Yaoyao Li; Mengkuan Lin; Darrick Lo; Judith Mizrachi; Stephanie Mok; Philip R Nicovich; Ramesh Palaniswamy; Jason Palmer; Xiaoli Qi; Elise Shen; Yu-Chi Sun; Huizhong W Tao; Wayne Wakemen; Yimin Wang; Shenqin Yao; Jing Yuan; Huiqing Zhan; Muye Zhu; Lydia Ng; Li I Zhang; Byung Kook Lim; Michael Hawrylycz; Hui Gong; James C Gee; Yongsoo Kim; Kwanghun Chung; X William Yang; Hanchuan Peng; Qingming Luo; Partha P Mitra; Anthony M Zador; Hongkui Zeng; Giorgio A Ascoli; Z Josh Huang; Pavel Osten; Julie A Harris; Hong-Wei Dong;

  • 作者单位

    Cold Spring Harbor Laboratory;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine University of California Los Angeles|USC Stevens Neuroimaging and Informatics Institute (INI) Keck School of Medicine of USC University of Southern California;

    Cold Spring Harbor Laboratory;

    Cold Spring Harbor Laboratory|Allen Institute for Brain Science;

    Allen Institute for Brain Science;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine University of California Los Angeles|USC Stevens Neuroimaging and Informatics Institute (INI) Keck School of Medicine of USC University of Southern California;

    Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics MoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology|HUST-Suzhou Institute for Brainsmatics JITRI;

    Cold Spring Harbor Laboratory;

    Allen Institute for Brain Science|Cajal Neuroscience;

    Cold Spring Harbor Laboratory;

    Cold Spring Harbor Laboratory;

    USC Stevens Neuroimaging and Informatics Institute (INI) Keck School of Medicine of USC University of Southern California;

    Center for Neurobehavioral Genetics Jane and Terry Semel Institute for Neuroscience and Human Behavior Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine at UCLA;

    Institute for Medical Engineering and Science Department of Chemical Engineering Picower Institute for Learning and Memory Massachusetts Institute of Technology (MIT);

    USC Stevens Neuroimaging and Informatics Institute (INI) Keck School of Medicine of USC University of Southern California|Department of Physiology and Neuroscience Zilkha Neurogenetic Institute Keck School of Medicine of USC University of Southern California;

    Department of Neural and Behavioral Sciences College of Medicine Penn State University;

    Center for Neural Informatics;

    Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics MoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology|HUST-Suzhou Institute for Brainsmatics JITRI;

    Allen Institute for Brain Science;

    Allen Institute for Brain Science;

    SEU-ALLEN Joint Center Institute for Brain and Intelligence Southeast University;

    SEU-ALLEN Joint Center Institute for Brain and Intelligence Southeast University;

    Cold Spring Harbor Laboratory;

    Cold Spring Harbor Laboratory|Department of Neurobiology Duke University School of Medicine;

    Center for Neural Informatics;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine University of California Los Angeles|USC Stevens Neuroimaging and Informatics Institute (INI) Keck School of Medicine of USC University of Southern California;

    Cold Spring Harbor Laboratory;

    Allen Institute for Brain Science;

    SEU-ALLEN Joint Center Institute for Brain and Intelligence Southeast University;

    Cold Spring Harbor Laboratory;

    Allen Institute for Brain Science;

    Cold Spring Harbor Laboratory;

    Cold Spring Harbor Laboratory;

    Cold Spring Harbor Laboratory;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine University of California Los Angeles|USC Stevens Neuroimaging and Informatics Institute (INI) Keck School of Medicine of USC University of Southern California;

    Cold Spring Harbor Laboratory;

    Allen Institute for Brain Science;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine University of California Los Angeles|USC Stevens Neuroimaging and Informatics Institute (INI) Keck School of Medicine of USC University of Southern California;

    Department of Biological Sciences University of Southern California;

    Cold Spring Harbor Laboratory|Department of Neurobiology Duke University School of Medicine;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine University of California Los Angeles|USC Stevens Neuroimaging and Informatics Institute (INI) Keck School of Medicine of USC University of Southern California;

    Center for Neural Circuits and Sensory Processing Disorders Zilkha Neurogenetics Institute (ZNI) Department of Physiology and Neuroscience Keck School of Medicine University of Southern California;

    Cold Spring Harbor Laboratory;

    School of Optometry and Ophthalmology Wenzhou Medical University;

    Allen Institute for Brain Science;

    Cold Spring Harbor Laboratory;

    School of Optometry and Ophthalmology Wenzhou Medical University;

    Cold Spring Harbor Laboratory;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine University of California Los Angeles|USC Stevens Neuroimaging and Informatics Institute (INI) Keck School of Medicine of USC University of Southern California;

    Cold Spring Harbor Laboratory;

    Allen Institute for Brain Science;

    Allen Institute for Brain Science|Cajal Neuroscience;

    Cold Spring Harbor Laboratory;

    Cold Spring Harbor Laboratory;

    Cold Spring Harbor Laboratory;

    Allen Institute for Brain Science;

    Cold Spring Harbor Laboratory;

    Center for Neural Circuits and Sensory Processing Disorders Zilkha Neurogenetics Institute (ZNI) Department of Physiology and Neuroscience Keck School of Medicine University of Southern California;

    Allen Institute for Brain Science;

    SEU-ALLEN Joint Center Institute for Brain and Intelligence Southeast University|School of Computer Engineering and Science Shanghai University;

    Allen Institute for Brain Science;

    Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics MoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology|HUST-Suzhou Institute for Brainsmatics JITRI;

    Cold Spring Harbor Laboratory;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine University of California Los Angeles|USC Stevens Neuroimaging and Informatics Institute (INI) Keck School of Medicine of USC University of Southern California;

    Allen Institute for Brain Science;

    Center for Neural Circuits and Sensory Processing Disorders Zilkha Neurogenetics Institute (ZNI) Department of Physiology and Neuroscience Keck School of Medicine University of Southern California;

    HUST-Suzhou Institute for Brainsmatics JITRI|Division of Biological Science Neurobiology section University of California San Diego;

    Allen Institute for Brain Science;

    Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics MoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology|HUST-Suzhou Institute for Brainsmatics JITRI;

    Department of Radiology University of Pennsylvania;

    Department of Neural and Behavioral Sciences College of Medicine Penn State University;

    Institute for Medical Engineering and Science Department of Chemical Engineering Picower Institute for Learning and Memory Massachusetts Institute of Technology (MIT);

    Center for Neurobehavioral Genetics Jane and Terry Semel Institute for Neuroscience and Human Behavior Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine at UCLA;

    SEU-ALLEN Joint Center Institute for Brain and Intelligence Southeast University;

    Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics MoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology|HUST-Suzhou Institute for Brainsmatics JITRI;

    Cold Spring Harbor Laboratory;

    Cold Spring Harbor Laboratory;

    Allen Institute for Brain Science;

    Center for Neural Informatics;

    Cold Spring Harbor Laboratory|Department of Neurobiology Duke University School of Medicine;

    Cold Spring Harbor Laboratory;

    Allen Institute for Brain Science|Cajal Neuroscience;

    UCLA Brain Research and Artificial Intelligence Nexus Department of Neurobiology David Geffen School of Medicine University of California Los Angeles|USC Stevens Neuroimaging and Informatics Institute (INI) Keck School of Medicine of USC University of Southern California;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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