It started life in French as le controle du milieu interne, and then picked up a Greek name — homeostasis. The idea, that in whole animals or single cells physiological parameters are regulated close to a constant value, is an old one. But homeostatic fixed points can change. A shift in the concentration of chloride during development changes the signalling between neurons that release the neurotransmitter GABA (γ-aminobutyric acid) and their target cells from positive to negative. And, reporting on page 251 of this issue, Rivera et al. have pinned down a molecule that maybe responsible for this switch.
展开▼
机译：它以法语“ le controle du milieu interne”开始生活，然后取了一个希腊名字-动态平衡。在整个动物或单个细胞中将生理参数调节到接近恒定值的想法是一个古老的想法。但是体内稳态点可以改变。发育过程中氯离子浓度的变化将释放神经递质GABA（γ-氨基丁酸）的神经元与其靶细胞之间的信号传递从正变为负。而且，Rivera等人在本期第251页进行了报道。已经确定了可能导致这种转换的分子。
展开▼
