Rhapsody in G proteins

Johannes L. Bos; Fried J. T. Zwartkruis

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Rhapsody in G proteins

机译：G蛋白狂想曲

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Guanine-nucleotide-binding (G) proteins are molecular switches that regulate a variety of cellular processes, transducing the signals received at a cell's surface to elicit a proper biological response from the proteins inside. They come in two flavours — the heterotrimeric G proteins and the small GTPases — and both can be regulated in two ways. The first involves the guanine-nudeotide-exchange factors (GEFs), which induce formation of the GTP-bound (active) form of the G protein. The second invokes the G proteins' intrinsic GTPase activity, which, by hydrolysing GTP to GDP, induces an inactive conformation. This hydrolysing activity can be greatly enhanced by GTPase-activating proteins (GAPs).

机译：鸟嘌呤核苷酸结合（G）蛋白是调节多种细胞过程的分子开关，转导细胞表面接收到的信号以从内部蛋白引起适当的生物学反应。它们具有两种风味-异源三聚体G蛋白和小的GTPases-两者可以通过两种方式进行调节。第一个涉及鸟嘌呤-核苷酸交换因子（GEFs），它诱导G蛋白结合（活性）形式的G蛋白形成。第二个调用G蛋白的固有GTPase活性，该活性通过将GTP水解为GDP诱导失活构象。 GTPase激活蛋白（GAPs）可以大大增强这种水解活性。

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《Nature》 |1999年第6747期|p.820-821|共2页
作者
Johannes L. Bos; Fried J. T. Zwartkruis;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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Rhapsody in G proteins

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