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Last days in Arcadia

机译:阿卡迪亚的最后几天

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摘要

The entire genetic code had been worked out by 1966. In a sense, this was not really a discovery. Obviously there had to be some kind of code and, in the end, it was deciphered more by brute force than subtle argument, using short molecules of RNA to drive protein synthesis in a test-tube. But the table showing the meaning of each of the 64 possible triplets was the culmination of all that had gone before. In the 13 years since Watson and Crick had revealed their model for the structure of DNA, the essential ingredients that handle biological information had been identified — DNA sequence, operons, repressors, messenger RNA, transfer RNA and ribosomes, plus the various classes of enzymes needed to make those ingredients. These were formidable discoveries, and they changed the science of molecular biology from an esoteric field inhabited by a small coterie into the discipline that has dominated biology ever since.
机译:整个遗传密码已在1966年制定出来。从某种意义上说,这并不是真正的发现。显然,必须有某种代码,最后,它是用蛮力而不是微妙的论点来解密的,它使用RNA的短分子在试管中驱动蛋白质合成。但是表格显示了这64种可能的三胞胎中每一种的含义,这是过去所有事物的最高潮。自Watson和Crick揭示其DNA结构模型以来的13年中,已经确定了处理生物学信息的基本成分-DNA序列,操纵子,阻遏物,信使RNA,转移RNA和核糖体,以及各种酶需要制作那些成分。这些都是令人敬畏的发现,它们将分子生物学的科学从一个小地方居住的神秘领域变成了自那时以来一直主导着生物学的学科。

著录项

  • 来源
    《Nature》 |1999年第6748期|p.19|共1页
  • 作者

    John Cairns;

  • 作者单位
  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

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