Myosin steps backwards

M Schliwa

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Myosin steps backwards

机译：肌球蛋白向后退

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Molecular motors are fascinating biological machines responsible for a variety of cellular movements. Some operate as individual molecules whose activities are visible only under sophisticated microscopes. Others cooperate in large ensembles of billions of molecules, allowing even gigantic animals to move. Yet the translocation of a tiny vesicle and the stomping of a dinosaur share an underlying mechanism at the level of a single motor molecule - the hydrolysis of one molecule of ATP leads to a small conformational change in the catalytic site. This change, in turn, is converted into a step of a few nanometres along a linear track.

机译：分子马达是引起各种细胞运动的迷人生物机器。一些作为单个分子起作用，其活性仅在复杂的显微镜下可见。其他人则以数十亿个分子的大集合合作，甚至允许巨型动物移动。然而，微小囊泡的移位和恐龙的踩踏在单个运动分子的水平上具有潜在的机制-一分子ATP的水解导致催化位点的构象变化很小。这种变化又沿着线性轨迹转换为几纳米的步长。

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《Nature》 |1999年第6752期|p.431-432|共2页
作者
M Schliwa;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport [J] . M. Yusuf Ali, Guy G. Kennedy, Daniel Safer, Proceedings of the National Academy of Sciences of the United States of America . 2011,第34期

机译：Myosin Va和Myosin VI在货物运输过程中进行体外拔河时协调了步伐
2. Stepping forward, stepping backward: a movement-related cortical potential study unveils distinctive brain activities [J] . Behavioural Brain Research: An International Journal . 2020,第期

机译：向前踩下，向后踩下：运动相关的皮质潜在研究揭示了独特的大脑活动
3. MARKETS, STATES AND THE FEDERAL GOVERNMENT IN THE TRANSITION TO WIND ENERGY: MANY STEPS FORWARD, AND RECENT STEPS BACKWARDS [J] . Shanti Gamper-Rabindran Journal of Land Use & Environmental Law . 2018,第2期

机译：市场向风能过渡的州，州和联邦政府：前进了许多步，倒退了许多步
4. Tracking of displacement steps generated by single myosin ID and myosin II molecules [C] . Ruff, C., Koehler, . 2002

机译：跟踪单个肌球蛋白ID和肌球蛋白II分子产生的置换步骤
5. The tale of the tail: The role of myosin VI tail domains in processive stepping [D] . Spink, Benjamin 2008

机译：尾巴的故事：肌球蛋白VI尾巴域在进行性步进中的作用
6. Spontaneous Detachment of the Leading Head Contributes to Myosin VI Backward Steps [O] . Keigo Ikezaki, Tomotaka Komori, Toshio Yanagida -1

机译：先行印刷头有助于自发支队肌球蛋白VI退步
7. Kinetic Model for Myosin Gating and Backward Stepping Mechanisms [O] . Mauro L. Mugnai, Matthew A. Caporizzo, Yale E. Goldman, 2019

机译：肌球蛋白门控和落后步进机制的动力学模型
8. Partial melting of the St. Severin (LL) and Lost City (H) ordinary chondrites: One step backwards and two steps forward [R] . Jurewicz, A. J. G., Jones, J. H., Mittlefehldt, D. W. 1994

机译：st. severin（LL）和Lost City（H）普通球粒陨石的部分融化：向后退一步，向前迈出两步

Myosin steps backwards

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