• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Stimulation by Rad52 of yeast Rad51-mediated recombination (see comments)
【24h】

Stimulation by Rad52 of yeast Rad51-mediated recombination (see comments)

机译：Rad52对酵母Rad51介导的重组的刺激（参见评论）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In Saccharomyces cerevisiae, the RAD51 and RAD52 genes are involved in recombination and in repair of damaged DNA. The RAD51 gene is a structural and functional homologue of the recA gene and the gene product participates in strand exchange and single-stranded-DNA-dependent ATP hydrolysis by means of nucleoprotein filament formation. The RAD52 gene is important in RAD51-mediated recombination. Binding of this protein to Rad51 suggests that they cooperate in recombination. Homologues of both Rad51 and Rad52 are conserved from yeast to humans, suggesting that the mechanisms used for pairing homologous DNA molecules during recombination may be universal in eukaryotes. Here we show that Rad52 protein stimulates Rad51 reactions and that binding to Rad51 is necessary for this stimulatory effect. We conclude that this binding is crucial in recombination and that it facilitates the formation of Rad51 nucleoprotein filaments.
机译：在酿酒酵母中，RAD51和RAD52基因参与重组和受损DNA的修复。 RAD51基因是recA基因的结构和功能同源物，该基因产物通过核蛋白丝形成参与链交换和依赖单链DNA的ATP水解。 RAD52基因在RAD51介导的重组中很重要。该蛋白与Rad51的结合表明它们在重组中协同作用。 Rad51和Rad52的同源物从酵母到人类都是保守的，这表明在重组过程中用于配对同源DNA分子的机制可能在真核生物中很普遍。在这里，我们显示Rad52蛋白刺激Rad51反应，并且与Rad51的结合对于这种刺激作用是必需的。我们得出结论，这种结合在重组中至关重要，并且它有助于Rad51核蛋白丝的形成。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号