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首页> 外文期刊>Nature >Requirement for IRF-1 in the microenvironment supporting development of natural killer cells (published erratum appears in Nature 1998 Apr 23;392(6678):843)
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Requirement for IRF-1 in the microenvironment supporting development of natural killer cells (published erratum appears in Nature 1998 Apr 23;392(6678):843)

机译：支持自然杀伤细胞发育的微环境对IRF-1的要求（发表的勘误表见Nature 1998 Apr 23; 392（6678）：843）

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摘要

Natural killer (NK) cells are critical for both innate and adaptive immunity. The development of NK cells requires interactions between their progenitors and the bone-marrow microenvironment; however, little is known about the molecular nature of such interactions. Mice that do not express the transcription factor interferon-regulatory factor-1 (IRF-1; such mice are IRF-1(-/-) mice) have been shown to exhibit a severe NK-cell deficiency. Here we demonstrate that the lack of IRF-1 affects the radiation-resistant cells that constitute the microenvironment required for NK-cell development, but not the NK-cell progenitors themselves. We also show that IRF-1(-/-) bone-marrow cells can generate functional NK cells when cultured with the cytokine interleukin-15 and that the interleukin-15 gene is transcriptionally regulated by IRF-1. These results reveal, for the first time, a molecular mechanism by which the bone-marrow microenvironment supports NK-cell development.
机译：天然杀伤（NK）细胞对于先天免疫和适应性免疫都至关重要。 NK细胞的发育需要其祖细胞与骨髓微环境之间的相互作用。然而，对于这种相互作用的分子性质了解甚少。不表达转录因子干扰素调节因子-1（IRF-1；此类小鼠是IRF-1（-/-）小鼠）的小鼠已显示出严重的NK细胞缺乏症。在这里，我们证明缺乏IRF-1会影响构成NK细胞发育所需的微环境的抗辐射细胞，但不会影响NK细胞祖细胞本身。我们还显示，IRF-1（-/-）骨髓细胞与细胞因子白介素15一起培养时可以产生功能性NK细胞，而白介素15基因受IRF-1转录调控。这些结果首次揭示了骨髓微环境支持NK细胞发育的分子机制。

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