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首页> 外文期刊>Nature >Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction.
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Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction.

机译：对编码融合抗原的，针对免疫诱导位点的DNA疫苗的反应增强。

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Viral infection and vaccination with DNA both induce similar immune responses to encoded antigens that are produced by the host. The availability of antigens in lymphoid organs is important in generating an immune response to viral challenge. Antigen availability may also be important in the response to DNA vaccines, because immune responses are stronger when antigen is secreted from DNA-transfected cells. We directed antigen to lymphoid organs by vaccination with DNA encoding antigen-ligand fusion proteins. The two ligands examined bind to receptors that are present on high endothelial venule cells of lymph nodes or on antigen-presenting cells. Here we show that both the humoral and the cellular immune responses to a model DNA vaccine were enhanced using either antigen-targeting strategy. Moreover, directing antigen to antigen-presenting cells speeded up, and altered the form of, the immune response. Directing antigen to sites of immune-response induction may represent a generic means of tailoring a potent and effective immune response to a DNA vaccine.
机译：病毒感染和DNA疫苗接种均可诱导对宿主产生的编码抗原的类似免疫反应。淋巴器官中抗原的可用性对于产生针对病毒攻击的免疫反应非常重要。抗原的可用性在对DNA疫苗的反应中也可能很重要，因为当抗原从DNA转染的细胞中分泌出来时，免疫反应就会更强。通过接种编码抗原-配体融合蛋白的DNA，我们将抗原导向淋巴样器官。检查的两个配体与存在于淋巴结的高内皮小静脉细胞或抗原呈递细胞上的受体结合。在这里，我们表明，使用两种抗原靶向策略均增强了对模型DNA疫苗的体液和细胞免疫反应。此外，将抗原引导至抗原呈递细胞可加快免疫反应并改变免疫反应的形式。将抗原引导至免疫应答诱导位点可以代表针对DNA疫苗定制有效的有效免疫应答的通用手段。

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