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首页> 外文期刊>Nature >C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180 (see comments)
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C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180 (see comments)

机译：秀丽隐杆线虫的吞噬作用和细胞迁移蛋白CED-5与人DOCK180相似（见评论）

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摘要

During programmed cell death, cell corpses are rapidly engulfed. This engulfment process involves the recognition and subsequent phagocytosis of cell corpses by engulfing cells. How cell corpses are engulfed is largely unknown. Here we report that ced-5, a gene that is required for cell-corpse engulfment in the nematode Caenorhabditis elegans, encodes a protein that is similar to the human protein DOCK180 and the Drosophila melanogaster protein Myoblast City (MBC), both of which have been implicated in the extension of cell surfaces. ced-5 mutants are defective not only in the engulfment of cell corpses but also in the migrations of two specific gonadal cells, the distal tip cells. The expression of human DOCK180 in C. elegans rescued the cell-migration defect of a ced-5 mutant. We present evidence that ced-5 functions in engulfing cells during the engulfment of cell corpses. We suggest that ced-5 acts in the extension of the surface of an engulfing cell around a dying cell during programmed cell death. We name this new family of proteins that function in the extension of cell surfaces the CDM (for CED-5, DOCK180 and MBC) family.
机译：在程序性细胞死亡期间，细胞尸体迅速被吞噬。该吞噬过程涉及通过吞噬细胞来识别和随后吞噬细胞尸体。细胞尸体是如何被吞噬的很大程度上是未知的。在这里我们报道ced-5是线虫秀丽隐杆线虫细胞尸体吞噬所需的基因，其编码的蛋白质类似于人蛋白质DOCK180和果蝇果蝇蛋白质成肌细胞（MBC），两者都有与细胞表面的扩展有关。 ced-5突变体不仅在细胞尸体的吞噬中有缺陷，而且在两个特定的性腺细胞（远端尖端细胞）的迁移中也有缺陷。秀丽隐杆线虫中人DOCK180的表达挽救了ced-5突变体的细胞迁移缺陷。我们目前提供证据，ce-5在吞噬细胞的过程中吞噬细胞。我们建议ced-5在程序性细胞死亡过程中作用于垂死细胞周围吞噬细胞表面的延伸。我们将这个新的蛋白质家族命名为在CDM（对于CED-5，DOCK180和MBC）家族的细胞表面扩展中起作用。

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