Purposeful mutations

Myron F. Goodman

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Purposeful mutations

机译：有目的的突变

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When DNA is passed from mother to daughter cells during replication, several mechanisms ensure that this occurs with a minimum of mutations. These include proofreading exonucleases and post-replication mismatch-repair enzymes. Nevertheless, "there's many a slip 'twixt the cup and the lip", such as the spontaneous loss of DNA bases and DNA damage from external sources. Many cells contain systems to repair damaged DNA, but Escherichia coli also harbours proteins that do the opposite — they reduce replication fidelity. These proteins are induced in response to DNA damage as part of the so-called SOS response, and reports by Bacher Reuven et al. in Molecular Cell and Tang et al. in Proceedings of the National Academy of Sciences detail the biochemical reconstitu-tion of this system.

机译：当DNA在复制过程中从母体细胞传递到子体细胞时，有几种机制可确保这种发生的突变最少。这些包括校对核酸外切酶和复制后错配修复酶。但是，“杯子和嘴唇都滑了很多”，例如DNA碱基的自发丢失和外部来源的DNA损伤。许多细胞都包含修复受损DNA的系统，但大肠杆菌还含有相反的蛋白质-它们会降低复制保真度。这些蛋白质是作为对DNA损伤的响应而诱导的，是所谓的SOS响应的一部分，据Bacher Reuven等报道。在分子细胞和唐等人。在《美国国家科学院院刊》上的文章详细介绍了该系统的生化重构。

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《Nature》 |1998年第6699期|p.221223|共2页
作者
Myron F. Goodman;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. AID-initiated purposeful mutations in immunoglobulin genes. [J] . Goodman MF, Scharff MD, Romesberg FE Advances in immunology . 2007,第0期

机译：AID启动的免疫球蛋白基因的有目的突变。
2. Leader Purposefulness within Servant Leadership: Examining the Effect of Servant Leadership, Leader Follower-Focus, Leader Goal-Orientation, and Leader Purposefulness in a Large U.S. Healthcare Organization [J] . Justin A. Irving, Julie Berndt Administrative Sciences . 2017,第2期

机译：仆人领导中的领导者目的性：检查大型美国医疗保健组织中仆人领导力，领导者关注者焦点，领导者目标取向和领导者目的性的影响
3. Describing of a Case of Purposeful Behavior of Living System in Which There Is No Contradiction Between Purposefulness and Physical Causality (or Cybernetics Does Live, Yes, It Lives!) [J] . O.V. SOLOVIOV Journal of automation and information sciences . 2002,第4期

机译：描述一例有目的的生命系统行为，其中目的性与物理因果关系之间没有矛盾（或者控制论确实存在，是的，它存在！）
4. PAS-MUT with Somatic Mutations in Cancer and Classified Diseases for Clinical-Genomics Research: PAS-MUT Somatic Mutations [C] . Saman Zeeshan, Zeeshan Ahmed IEEE International Conference on Bioinformatics and Biomedicine . 2019

机译：具有癌症和分类疾病中的体细胞突变的PAS-MUT用于临床基因组学研究：PAS-MUT和体细胞突变
5. Computational assessment of somatic missense mutations detected in tumor sequencing studies with cancer-specific high-throughput annotation of somatic mutations (CHASM). [D] . Carter, Hannah. 2012

机译：具有肿瘤特异性高通量体细胞突变（CHASM）的肿瘤测序研究中检测到的体细胞错义突变的计算评估。
6. ‘Prescription’ for Purposeful Adaptation of Professionalism-and-Ethics Teaching Strategies for Remote Delivery [O] . Cicely Roche 2021

机译：处方目的适应专业性和伦理教学策略用于远程交付
7. Purposeful mutations [O] . Myron F. Goodman 1998

机译：有目的的突变
8. Complex Frameshift Mutations Mediated by Plasmid pKM101: Mutational MechanismsDeduced from 4-Aminobiphenyl-Induced Mutation Spectra in Salmonella [R] . Levine, J. G., Schaaper, R. M., DeMarini, D. M. 1994

机译：质粒pKm101介导的复杂移码突变：由4-氨基联苯诱导的沙门氏菌突变谱引起的突变机制

Purposeful mutations

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