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首页> 外文期刊>Nature >Signal-specific co-activator domain requirements for Pit-1 activation.
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Signal-specific co-activator domain requirements for Pit-1 activation.

机译：Pit-1激活的信号特定辅助激活域要求。

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摘要

POU-domain proteins, such as the pituitary-specific factor Pit-1, are members of the homeodomain family of proteins which are important in development and homeostasis, acting constitutively or in response to signal-transduction pathways to either repress or activate the expression of specific genes. Here we show that whereas homeodomain-containing repressors such as Rpx2 seem to recruit only a co-repressor complex, the activity of Pit-1 is determined by a regulated balance between a co-repressor complex that contains N-CoR/SMRT, mSin3A/B and histone deacetylases, and a co-activator complex that includes the CREB-binding protein (CBP) and p/CAF. Activation of Pit-1 by cyclic AMP or growth factors depends on distinct amino- and carboxy-terminal domains of CBP, respectively. Furthermore, the histone acetyltransferase functions of CBP or p/CAF are required for Pit-1 function that is stimulated by cyclic AMP or growth factors, respectively. These data show that there is a switch in specific requirements for histone acetyltransferases and CBP domains in mediating the effects of different signal-transduction pathways on specific DNA-bound transcription factors.
机译：POU域蛋白（例如垂体特异性因子Pit-1）是homeodomain蛋白家族的成员，这些蛋白在发育和体内稳态中起重要作用，其组成性或响应信号转导途径来抑制或激活PPAR-1的表达。特定基因。在这里，我们显示，虽然含Homeodomain的阻遏物（例如Rpx2）似乎仅募集共阻遏物复合物，但Pit-1的活性由含有N-CoR / SMRT的共阻遏物复合物，mSin3A /之间的调节平衡决定。 B和组蛋白脱乙酰基酶，以及包括CREB结合蛋白（CBP）和p / CAF的共激活复合物。环状AMP或生长因子对Pit-1的激活分别取决于CBP的不同氨基和羧基末端结构域。此外，Cit或p / CAF的组蛋白乙酰转移酶功能对于分别由环状AMP或生长因子刺激的Pit-1功能是必需的。这些数据表明，在介导不同信号转导途径对特定DNA结合转录因子的影响方面，对组蛋白乙酰基转移酶和CBP结构域的特定要求有所改变。

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