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首页> 外文期刊>Nature >Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo (see comments)
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Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo (see comments)

机译：鼠标胚胎中前后轴的正确方向需要加密（请参阅注释）

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摘要

The anterior-posterior axis of the mouse embryo is established by two distinct organizing centres in the anterior visceral endoderm and the distal primitive streak. These organizers induce and pattern the head and trunk respectively, and have been proposed to be localized through coordinate cell movements that rotate a pre-existing proximal-distal axis. Here we show that correct localization of both head- and trunk-organizing centres requires Cripto, a putative signalling molecule that is a member of the EGF-CFC gene family. Before gastrulation, Cripto is asymmetrically expressed in a proximal-distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm. A Cripto null mutation generated by targeted gene disruption results in homozygous Cripto-/- embryos that mostly consist of anterior neuroectoderm and lack posterior structures, thus resembling a head without a trunk. Notably, markers of the head organizer are located at the distal end of the embryo, whereas markers of the primitive streak are absent or localized to the proximal side. Our results indicate that Cripto signalling is essential for the conversion of a proximal-distal asymmetry into an orthogonal anterior-posterior axis.
机译：小鼠胚胎的前后轴由前内脏内胚层和远侧原始条纹中的两个不同的组织中心建立。这些组织器分别诱导和图案化头部和躯干，并已建议通过使先前存在的近端-远端轴旋转的坐标单元运动来定位。在这里，我们显示正确地定位头部和躯干组织中心都需要Cripto，这是一种推定的信号分子，是EGF-CFC基因家族的成员。在胃化之前，Cripto在上皮细胞的近端-远端梯度中不对称表达，随后在原始条带和新形成的胚胎中胚层中表达。由靶向基因破坏产生的Cripto无效突变导致纯合的Cripto-/-胚胎主要由前神经外胚层组成并且缺乏后部结构，因此类似于没有躯干的头部。值得注意的是，头部组织器的标记位于胚胎的远端，而原始条纹的标记则不存在或位于近端。我们的结果表明，Cripto信号对于将近端-远端不对称转换为正交的前后轴至关重要。

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