• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Episodic adaptive evolution of primate lysozymes.
【24h】

Episodic adaptive evolution of primate lysozymes.

机译：灵长类溶菌酶的间歇性适应性进化。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although the darwinian concept of adaptation was established nearly a century ago, it has been difficult to demonstrate rigorously that the amino-acid differences between homologous proteins from different species have adaptive significance. There are currently two major types of sequence tests for positive darwinian selection on proteins from different species: sequence convergence, and neutral rate violation (reviewed in ref. 1). Lysozymes from the stomachs of cows and langur monkeys, two mammalian species displaying fermentation in the foregut, are an example of amino-acid sequence convergence among homologous proteins. Here we combine tests of neutral rate violation with reconstruction of ancestral sequences to document an episode of positive selection on the lineage leading to the common ancestor of the foregut-fermenting colobine monkeys. This analysis also detected a previously unsuspected adaptive episode on the lineage leading to the common ancestor of the modern hominoid lysozymes. Both adaptive episodes were followed by episodes of negative selection. Thus this approach can detect adaptive and purifying episodes, and localize them to specific lineages during protein evolution.
机译：尽管达尔文的适应性概念已经建立了近一个世纪，但很难严格地证明来自不同物种的同源蛋白之间的氨基酸差异具有适应性意义。目前，对来自不同物种的蛋白质进行阳性达尔文选择的序列测试有两种主要类型：序列收敛和中性速率违反（参见参考文献1）。来自牛和叶猴的胃中的溶菌酶是在前肠中显示发酵的两种哺乳动物，是同源蛋白质之间氨基酸序列收敛的一个例子。在这里，我们结合中性速率违规测试与祖先序列的重建，以记录在谱系上出现正向选择的情节，从而导致前肠发酵后代猴的共同祖先。该分析还检测到谱系上先前未曾预料到的适应性发作，从而导致了现代人类溶菌酶的共同祖先。两次适应性发作后均出现负选择发作。因此，这种方法可以检测出适应性和纯化性发作，并在蛋白质进化过程中将其定位于特定谱系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号